Dibutyryl cAMP | Cell permeable cAMP
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 25 mg | $35.00 | ||
| 100 mg | $100.00 |
Dibutyryl cAMP (16980-89-5) is a cell-permeable cAMP analog which mimics the effect of endogenous cAMP when applied to cells.1 Activates PKA.2,3 Induces morphological differentiation of astrocytes.4 Promotes differentiation of dopaminergic neurons from hPSCs (in cocktails with other agents).5
References/Citations:
1) Bartsch et al. (2003), Bioactivatable, membrane-permeant analogs of cyclic nucleotides as biological tools for growth control of C6 glioma cells; Biol. Chem., 384 1321
2) Carranza et al. (1998), Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells; J. Physiol., 15 511
3) Hei et al. (1991), Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs; Mol. Pharmacol., 39 233
4) Imamura et al. (1998), Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes; Proc. Natl. Acad. Sci. USA, 95 6139
5) Xia et al. (2016), Transcriptional comparison of human induced and primary midbrain dopaminergic neurons; Sci. Rep., 6 20270
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Dibutyryl cAMP (16980-89-5) is a cell-permeable cAMP analog which mimics the effect of endogenous cAMP when applied to cells.1 Activates PKA.2,3 Induces morphological differentiation of astrocytes.4 Promotes differentiation of dopaminergic neurons from hPSCs (in cocktails with other agents).5
References/Citations:
1) Bartsch et al. (2003), Bioactivatable, membrane-permeant analogs of cyclic nucleotides as biological tools for growth control of C6 glioma cells; Biol. Chem., 384 1321
2) Carranza et al. (1998), Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells; J. Physiol., 15 511
3) Hei et al. (1991), Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs; Mol. Pharmacol., 39 233
4) Imamura et al. (1998), Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes; Proc. Natl. Acad. Sci. USA, 95 6139
5) Xia et al. (2016), Transcriptional comparison of human induced and primary midbrain dopaminergic neurons; Sci. Rep., 6 20270
Related products
-
Vinpocetine | PDE1 inhibitor
From $30.00CAS:42971-09-5Catalog Number:10-1126Activity:PDE1 inhibitorChemical Name:(3α,16α)-Eburnamenine-14-carboxylic acid ethyl esterMolecular Weight:350.45Molecular Formula:C22H26N2O2Solubility:Soluble in DMSO (up to 5 mg/ml), in ethanol (up to 15 mg/ml) or in DMF (up to 3 mg/ml with warming)Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO, Ethanol, or DMF may be stored at -20°C for up to 3 months.Shipping Code:RT -
Sulindac Sulfide | NFkappaB inhibitor
From $50.00CAS:49627-27-2Catalog Number:10-2156Activity:NFkappaB inhibitorChemical Name:(Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acidMolecular Weight:340.42Molecular Formula:C20H17FO2SSolubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:Yellow solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
Mycophenolate mofetil | Immunomodulator
From $40.00CAS:128794-94-5Catalog Number:10-2086Activity:ImmunomodulatorChemical Name:6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid 2-(4-morpholinyl)ethyl esterMolecular Weight:433.51Molecular Formula:C23H31NO7Solubility:Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 4 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
