Dibutyryl cAMP | Cell permeable cAMP
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 25 mg | $35.00 | ||
| 100 mg | $100.00 |
Dibutyryl cAMP (16980-89-5) is a cell-permeable cAMP analog which mimics the effect of endogenous cAMP when applied to cells.1 Activates PKA.2,3 Induces morphological differentiation of astrocytes.4 Promotes differentiation of dopaminergic neurons from hPSCs (in cocktails with other agents).5
References/Citations:
1) Bartsch et al. (2003), Bioactivatable, membrane-permeant analogs of cyclic nucleotides as biological tools for growth control of C6 glioma cells; Biol. Chem., 384 1321
2) Carranza et al. (1998), Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells; J. Physiol., 15 511
3) Hei et al. (1991), Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs; Mol. Pharmacol., 39 233
4) Imamura et al. (1998), Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes; Proc. Natl. Acad. Sci. USA, 95 6139
5) Xia et al. (2016), Transcriptional comparison of human induced and primary midbrain dopaminergic neurons; Sci. Rep., 6 20270
NMR (Conforms)
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Product Data Sheet:
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Dibutyryl cAMP (16980-89-5) is a cell-permeable cAMP analog which mimics the effect of endogenous cAMP when applied to cells.1 Activates PKA.2,3 Induces morphological differentiation of astrocytes.4 Promotes differentiation of dopaminergic neurons from hPSCs (in cocktails with other agents).5
References/Citations:
1) Bartsch et al. (2003), Bioactivatable, membrane-permeant analogs of cyclic nucleotides as biological tools for growth control of C6 glioma cells; Biol. Chem., 384 1321
2) Carranza et al. (1998), Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells; J. Physiol., 15 511
3) Hei et al. (1991), Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs; Mol. Pharmacol., 39 233
4) Imamura et al. (1998), Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes; Proc. Natl. Acad. Sci. USA, 95 6139
5) Xia et al. (2016), Transcriptional comparison of human induced and primary midbrain dopaminergic neurons; Sci. Rep., 6 20270
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