Dihydroouabain | Endogenous ouabain-like factor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $75.00 | ||
| 50 mg | $300.00 |
Dihydroouabain (DHO; 1183-35-3) has been identified as an endogenous ouabain-like effector of sodium-potassium ATPase in mouse1 and human2 adrenal cells. Micromolar to millimolar concentrations of DHO are known to inhibit Na/K pump activity3 and nanomolar concentrations stimulate Na/K pump activity in an isoform-specific manner4.
References/Citations:
- Qazzaz et al. (2000), Secretion of a lactone-hydrogenated ouabain-like effector of sodium, potassium-adenosine triphosphatase activity by adrenal cells; Endocrinology, 141 3200
- El-Masri et al. (2002), Human adrenal cells in culture produce both ouabain-like and dihydroouabain-like factors; Clin. Chem, 48 1720
- Bielen et al. (1992), The kinetics of the inhibition by dihydroouabain of the sodium pump current in single rabbit cardiac Purkinje cells; Naunyn Schmiedbergs Arch. Pharmacol., 345 100
- Gao et al. (2002), Isoform-specific stimulation of cardiac Na/K pumps by nanomolar concentrations of glycosides; J. Gen. Physiol., 119 297
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
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Dihydroouabain (DHO; 1183-35-3) has been identified as an endogenous ouabain-like effector of sodium-potassium ATPase in mouse1 and human2 adrenal cells. Micromolar to millimolar concentrations of DHO are known to inhibit Na/K pump activity3 and nanomolar concentrations stimulate Na/K pump activity in an isoform-specific manner4.
References/Citations:
- Qazzaz et al. (2000), Secretion of a lactone-hydrogenated ouabain-like effector of sodium, potassium-adenosine triphosphatase activity by adrenal cells; Endocrinology, 141 3200
- El-Masri et al. (2002), Human adrenal cells in culture produce both ouabain-like and dihydroouabain-like factors; Clin. Chem, 48 1720
- Bielen et al. (1992), The kinetics of the inhibition by dihydroouabain of the sodium pump current in single rabbit cardiac Purkinje cells; Naunyn Schmiedbergs Arch. Pharmacol., 345 100
- Gao et al. (2002), Isoform-specific stimulation of cardiac Na/K pumps by nanomolar concentrations of glycosides; J. Gen. Physiol., 119 297
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