Dihydroresveratrol | Resveratrol metabolite

CAS:
58436-28-5
Catalog Number:
10-2790
Activity:
Resveratrol metabolite
Chemical Name:
5-[2-(4-Hydroxyphenyl)ethyl]-1,3-benzenediol; 3,4′,5-trihydroxybibenzyl
Molecular Weight:
230.30
Molecular Formula:
C27H46O2
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 30 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by HPLC and TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
5 Mg$50.00
25 Mg$170.00

Dihydroresveratrol (58436-28-5) is a metabolite of resveratrol produced by gut microbiota.1-3 Glucoronide conjugates are found in human urine after oral intake of resveratrol-containing dietary supplements.4 Dihydroresveratrol glucoside is a potent melanogenesis inhibitor in B16F0 melanoma cells.5 Inactive analog of resveratrol in induction of premature senescence.6

References/Citations:

1) Jung et al. (2009), Interaction of dietary resveratrol with animal-associated bacteria; FEMS Microbiol. Lett., 297 266
2) Bode et al. (2013), In vivo and in vitro metabolism of trans-resveratrol by human gut microbiota; Am. J. Clin. Nutr., 97 295
3) Jarosova et al. (2019), Metabolism of Stilbenoids by Human Faecal Microbiota; Molecules, 24 E1155
4) Radco et al. (2013), Semi-preparative isolation of dihydroresveratrol-3-O-ß-d-glucuronide and four resveratrol conjugates from human urine after oral intake of a resveratrol-containing dietary supplement; J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 930 54
5) Oode et al. (2014), Synthesis of dihydroresveratrol glycosides and evaluation of their activity against melanogenesis in B16F0 melanoma cells; Eur. J. Med. Chem., 87 862
6) Faragher et al. (2011), Resveratrol, but not dihydroresveratrol, induces premature senescence in primary human fibroblasts; Age (Dordr.), 33 555

CAS:
58436-28-5
Catalog Number:
10-2790
Activity:
Resveratrol metabolite
Chemical Name:
5-[2-(4-Hydroxyphenyl)ethyl]-1,3-benzenediol; 3,4′,5-trihydroxybibenzyl
Molecular Weight:
230.30
Molecular Formula:
C27H46O2
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 30 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by HPLC and TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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