Diltiazem | Calcium channel blocker
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 1 gram | $50.00 | ||
| 5 gram | $140.00 |
Diltiazem HCl (33286-22-5) is a non-dihydropyridine-type blocker of L-type Ca2+ channels.1,2 Reduces Ca2+ oscillations in subcellular compartments in vascular smooth muscle cells.3 Also blocks P-type Ca2+ channels in freshly dissociated rat cerebellar Purkinje neurons.4 Clinically useful antihypertensive agent.5 Cell permeable.
References/Citations:
1) Kraus et al. (1998), Molecular mechanism of diltiazem interaction with L-type Ca2+ channels; J. Biol. Chem., 273 27205
2) Godfraind et al. (1986), Calcium antagonism and calcium entry blockade; Pharmacol. Rev., 38 321
3) Fedoryak et al. (2004), Spontaneous Ca2+ oscillations in subcellular compartments of vascular smooth muscle cells rely on different Ca2+ pools; Cell Res., 14 379
4) Ishibashi et al. (1995), Block of P-type Ca2+ channels in freshly dissociated rat cerebellar Purkinje neurons by diltiazem and verapamil; Brain Res., 695 88
5) Chaffman and Bogden (1985), Diltiazem. A review of its pharmacological properties and therapeutic efficacy; Drugs, 29 387
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Diltiazem HCl (33286-22-5) is a non-dihydropyridine-type blocker of L-type Ca2+ channels.1,2 Reduces Ca2+ oscillations in subcellular compartments in vascular smooth muscle cells.3 Also blocks P-type Ca2+ channels in freshly dissociated rat cerebellar Purkinje neurons.4 Clinically useful antihypertensive agent.5 Cell permeable.
References/Citations:
1) Kraus et al. (1998), Molecular mechanism of diltiazem interaction with L-type Ca2+ channels; J. Biol. Chem., 273 27205
2) Godfraind et al. (1986), Calcium antagonism and calcium entry blockade; Pharmacol. Rev., 38 321
3) Fedoryak et al. (2004), Spontaneous Ca2+ oscillations in subcellular compartments of vascular smooth muscle cells rely on different Ca2+ pools; Cell Res., 14 379
4) Ishibashi et al. (1995), Block of P-type Ca2+ channels in freshly dissociated rat cerebellar Purkinje neurons by diltiazem and verapamil; Brain Res., 695 88
5) Chaffman and Bogden (1985), Diltiazem. A review of its pharmacological properties and therapeutic efficacy; Drugs, 29 387
Related products
-
Mifepristone | Glucocorticoid antagonist
From $50.00CAS:84371-65-3Catalog Number:10-1053Activity:Glucocorticoid antagonistAlternate Names:RU486Chemical Name:11β-[4-(Dimethylamino)phenyl]-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-oneMolecular Weight:429.59Molecular Formula:C29H35NO2Solubility:Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml).Physical Properties:Yellow solidPurity:>98% by TLCStorage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
Cyclosporin A | Inhibits mitochondrial permeability pore opening
From $50.00CAS:59865-13-3Catalog Number:10-1119Activity:Inhibits mitochondrial permeability pore openingMolecular Weight:1202.65Molecular Formula:C62H111N11O12Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:White solidPurity:99% by TLCStorage Temperature:-20°CStability:Stable for 3 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
Rosiglitazone maleate | PPAR gamma agonist
From $55.00CAS:155141-29-0Catalog Number:10-1012Activity:PPARγ agonistAlternate Names:Avandia; BRL49653Chemical Name:5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione maleateMolecular Weight:357.43Molecular Formula:C18H19N3O3SSolubility:Soluble in DMSO (up to 50 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 monthsShipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
