Size : | Price | Quantity | |
---|---|---|---|
1 gram | $50.00 | ||
5 gram | $140.00 |
Diltiazem HCl (33286-22-5) is a non-dihydropyridine-type blocker of L-type Ca2+ channels.1,2 Reduces Ca2+ oscillations in subcellular compartments in vascular smooth muscle cells.3 Also blocks P-type Ca2+ channels in freshly dissociated rat cerebellar Purkinje neurons.4 Clinically useful antihypertensive agent.5 Cell permeable.
References/Citations:
1) Kraus et al. (1998), Molecular mechanism of diltiazem interaction with L-type Ca2+ channels; J. Biol. Chem., 273 27205
2) Godfraind et al. (1986), Calcium antagonism and calcium entry blockade; Pharmacol. Rev., 38 321
3) Fedoryak et al. (2004), Spontaneous Ca2+ oscillations in subcellular compartments of vascular smooth muscle cells rely on different Ca2+ pools; Cell Res., 14 379
4) Ishibashi et al. (1995), Block of P-type Ca2+ channels in freshly dissociated rat cerebellar Purkinje neurons by diltiazem and verapamil; Brain Res., 695 88
5) Chaffman and Bogden (1985), Diltiazem. A review of its pharmacological properties and therapeutic efficacy; Drugs, 29 387
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Diltiazem HCl (33286-22-5) is a non-dihydropyridine-type blocker of L-type Ca2+ channels.1,2 Reduces Ca2+ oscillations in subcellular compartments in vascular smooth muscle cells.3 Also blocks P-type Ca2+ channels in freshly dissociated rat cerebellar Purkinje neurons.4 Clinically useful antihypertensive agent.5 Cell permeable.
References/Citations:
1) Kraus et al. (1998), Molecular mechanism of diltiazem interaction with L-type Ca2+ channels; J. Biol. Chem., 273 27205
2) Godfraind et al. (1986), Calcium antagonism and calcium entry blockade; Pharmacol. Rev., 38 321
3) Fedoryak et al. (2004), Spontaneous Ca2+ oscillations in subcellular compartments of vascular smooth muscle cells rely on different Ca2+ pools; Cell Res., 14 379
4) Ishibashi et al. (1995), Block of P-type Ca2+ channels in freshly dissociated rat cerebellar Purkinje neurons by diltiazem and verapamil; Brain Res., 695 88
5) Chaffman and Bogden (1985), Diltiazem. A review of its pharmacological properties and therapeutic efficacy; Drugs, 29 387
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