DiMNF | AhR modulator (SAhRM)
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 10 mg | $50.00 | ||
| 50 mg | $190.00 |
DiMNF (14756-24-2) is a selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). It exhibits antiinflammatory activity including suppression of cytokine-mediated acute phase genes through dissociation of non-dioxin-response element (DRE) AHR activity from DRE-dependent xenobiotic gene expression.1 DiMNF represses the cytokine-mediated induction of CD55 and therefore may have therapeutic potential in regulating the immune response to tumor formation.2 Represses estrogen-inducible transcription.3
References/Citations:
1) Murray et al. (2011), Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3’,4’-dimethoxy-α-naphthoflavone; Mol. Pharmacol., 79 508
2) Narayanan et al. (2012), Selective aryl hydrocarbon receptor modulator-mediated repression of CD55 expression induced by cytokine exposure; J. Pharmacol. Exp. Ther., 342 345
3) Labrecque et al. (2012), Distinct roles for aryl hydrocarbon receptor nuclear translocator and ah receptor in estrogen-mediated signaling in human cancer cell lines; PLoS One, 7(1) e29545
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
DiMNF (14756-24-2) is a selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). It exhibits antiinflammatory activity including suppression of cytokine-mediated acute phase genes through dissociation of non-dioxin-response element (DRE) AHR activity from DRE-dependent xenobiotic gene expression.1 DiMNF represses the cytokine-mediated induction of CD55 and therefore may have therapeutic potential in regulating the immune response to tumor formation.2 Represses estrogen-inducible transcription.3
References/Citations:
1) Murray et al. (2011), Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3’,4’-dimethoxy-α-naphthoflavone; Mol. Pharmacol., 79 508
2) Narayanan et al. (2012), Selective aryl hydrocarbon receptor modulator-mediated repression of CD55 expression induced by cytokine exposure; J. Pharmacol. Exp. Ther., 342 345
3) Labrecque et al. (2012), Distinct roles for aryl hydrocarbon receptor nuclear translocator and ah receptor in estrogen-mediated signaling in human cancer cell lines; PLoS One, 7(1) e29545
Related products
-
MK-571 | Cys LT1 antagonist
From $60.00CAS:115104-28-4Catalog Number:10-1039Activity:Cys LT1 antagonistAlternate Names:L-660711Chemical Name:5-(3-(2-(7-Chloroquinolin-2-yl)ethenyl)phenyl)-8-dimethylcarbamyl-4,6-dithiaoctanoic acidMolecular Weight:515.09Molecular Formula:C26H27ClN2O3S2Solubility:Soluble in DMSO (up to 50 mg/ml).Physical Properties:Yellow solidPurity:95% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.Shipping Code:RT -
Dexamethasone | Apoptosis inducing glucocorticoid
From $60.00CAS:50-02-2Catalog Number:10-1134Activity:Apoptosis inducing glucocorticoidChemical Name:(11α,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dioneMolecular Weight:392.46Molecular Formula:C22H29FO5Solubility:Soluble in DMSO (up to 40 mg/ml).Physical Properties:White solidPurity:98%
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 monthsShipping Code:RT -
GSK-J1 | JMJ H3K27 Demethylase inhibitor (Non-cell permeable)
From $75.00CAS:1373422-53-7Catalog Number:10-1393Activity:JMJ H3K27 Demethylase inhibitor (Non-cell permeable)Chemical Name:N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanineMolecular Weight:389.46Molecular Formula:C22H23N5O2Solubility:Soluble in DMSO (up to 20 mg/ml).Physical Properties:Pale yellow solidPurity:99% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
