DiMNF | AhR modulator (SAhRM)
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 10 mg | $50.00 | ||
| 50 mg | $190.00 |
DiMNF (14756-24-2) is a selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). It exhibits antiinflammatory activity including suppression of cytokine-mediated acute phase genes through dissociation of non-dioxin-response element (DRE) AHR activity from DRE-dependent xenobiotic gene expression.1 DiMNF represses the cytokine-mediated induction of CD55 and therefore may have therapeutic potential in regulating the immune response to tumor formation.2 Represses estrogen-inducible transcription.3
References/Citations:
1) Murray et al. (2011), Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3’,4’-dimethoxy-α-naphthoflavone; Mol. Pharmacol., 79 508
2) Narayanan et al. (2012), Selective aryl hydrocarbon receptor modulator-mediated repression of CD55 expression induced by cytokine exposure; J. Pharmacol. Exp. Ther., 342 345
3) Labrecque et al. (2012), Distinct roles for aryl hydrocarbon receptor nuclear translocator and ah receptor in estrogen-mediated signaling in human cancer cell lines; PLoS One, 7(1) e29545
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
DiMNF (14756-24-2) is a selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). It exhibits antiinflammatory activity including suppression of cytokine-mediated acute phase genes through dissociation of non-dioxin-response element (DRE) AHR activity from DRE-dependent xenobiotic gene expression.1 DiMNF represses the cytokine-mediated induction of CD55 and therefore may have therapeutic potential in regulating the immune response to tumor formation.2 Represses estrogen-inducible transcription.3
References/Citations:
1) Murray et al. (2011), Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3’,4’-dimethoxy-α-naphthoflavone; Mol. Pharmacol., 79 508
2) Narayanan et al. (2012), Selective aryl hydrocarbon receptor modulator-mediated repression of CD55 expression induced by cytokine exposure; J. Pharmacol. Exp. Ther., 342 345
3) Labrecque et al. (2012), Distinct roles for aryl hydrocarbon receptor nuclear translocator and ah receptor in estrogen-mediated signaling in human cancer cell lines; PLoS One, 7(1) e29545
Related products
-
WY-14643 | PPARα agonist
From $65.00CAS:50892-23-4Catalog Number:10-1137Activity:PPARα agonistAlternate Names:Pirinixic acidChemical Name:4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acidMolecular Weight:323.8Molecular Formula:C14H14ClN2O2SSolubility:Soluble in DMSO (up to 40 mg/ml).Physical Properties:Off-white solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 6 months.Shipping Code:RT -
Zafirlukast | HSP70 inhibitor and leukotriene antagonist
From $28.00CAS:107753-78-6Catalog Number:10-1100Activity:Hsp70 inhibitorAlternate Names:ICI-204219Molecular Weight:575.69Molecular Formula:C31H33N3O6SSolubility:Soluble in DMSO (up to 10 mg/ml).Physical Properties:White or pink solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years as supplied. Protect from exposure to moisture. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
Palmitoylethanolamide | GPR55 agonist
From $60.00CAS:544-31-0Catalog Number:10-1297Activity:GPR55 agonistAlternate Names:PEAChemical Name:N-(2-Hydroxyethyl)palmitamideMolecular Weight:299.49Molecular Formula:C18H37NO2Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
