Diphenyleneiodonium chloride | Flavoprotein inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $55.00 | ||
| 50 mg | $220.00 |
Diphenyleneiodonium chloride (4673-26-1) is an irreversible inhibitor of iNOS and eNOS (IC50s=50 and 100 nM respectively).1 Binds to and inhibits the flavoprotein of neutrophil NADPH oxidase.2 Novel agonist for GPR3.3 Inhibits NFκB activation induced by IL-1β.4 Prevents early alcohol-induced liver injury in rodent models.5
References/Citations:
1) Stuehr et al. (1991), Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs; FASEB J., 5 98
2) Yea et al. (1990), Purification and some properties of the 45 kDa diphenylene iodonium-binding flavoprotein of neutrophil NADPH oxidase; Biochem. J., 265 95
3) Ye et al. (2014), Identification of a novel small-molecule agonist for human G protein-coupled receptor 3; J. Pharmacol. Exp. Ther., 349 4371
4) Mendes et al. (2001), Diphenyleneiodonium inhibits NF-kappaB activation and iNOS expression induced by IL-1beta: involvement of reactive oxygen species; Mediators Inflamm., 10 209
5) Kono et al. (2001), Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat; Am. J. Physiol. Gastrointest. Liver Physiol., 280 G1005
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Diphenyleneiodonium chloride (4673-26-1) is an irreversible inhibitor of iNOS and eNOS (IC50s=50 and 100 nM respectively).1 Binds to and inhibits the flavoprotein of neutrophil NADPH oxidase.2 Novel agonist for GPR3.3 Inhibits NFκB activation induced by IL-1β.4 Prevents early alcohol-induced liver injury in rodent models.5
References/Citations:
1) Stuehr et al. (1991), Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs; FASEB J., 5 98
2) Yea et al. (1990), Purification and some properties of the 45 kDa diphenylene iodonium-binding flavoprotein of neutrophil NADPH oxidase; Biochem. J., 265 95
3) Ye et al. (2014), Identification of a novel small-molecule agonist for human G protein-coupled receptor 3; J. Pharmacol. Exp. Ther., 349 4371
4) Mendes et al. (2001), Diphenyleneiodonium inhibits NF-kappaB activation and iNOS expression induced by IL-1beta: involvement of reactive oxygen species; Mediators Inflamm., 10 209
5) Kono et al. (2001), Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat; Am. J. Physiol. Gastrointest. Liver Physiol., 280 G1005
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