Dipyridamole | Pan-specific PDE inhibitor

CAS:
58-32-2
Catalog Number:
10-1095
Activity:
Pan-specific PDE inhibitor
Chemical Name:
2,6-bis(Diethanolamino)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine
Alternate Names:
NSC-515776
Molecular Weight:
504.63
Molecular Formula:
C24H40N8O4
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 5 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
1 gram$30.00

Dipyridamole (58-32-2) is a phosphodiesterase inhibitor (IC50=0.37, 0.38, 0.45, 0.9 and 4.5 μM for PDE11, 6, 10, 5 and 8 respectively.1,2 Potent equilibrative nucleoside transporter 1 (ENT1) inhibitor Ki=8.2 nM vs. 144.8 nM for ENT1 and ENT2 respectively.3 Antiplatelet activity.4

References/Citations:

1) Fujishige et al. (1999), Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A); J. Biol. Chem., 274 18438
2) Soderling et al. (1998), Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase; Proc. Natl. Acad. Sci. USA, 95 8991
3) Lin and Buolamwini (2007), Synthesis, flow cytometric evaluation, and identification of highly potent dipyridamole analogues as equilibrative nucleoside transporter 1 inhibitors.; J. Med. Chem., 50 3906
4) Coccheri (2010), Antiplatelet drugs – do we need new options? With a reappraisal of direct thromboxane inhibitors; Drugs, 70 887

CAS:
58-32-2
Catalog Number:
10-1095
Activity:
Pan-specific PDE inhibitor
Chemical Name:
2,6-bis(Diethanolamino)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine
Alternate Names:
NSC-515776
Molecular Weight:
504.63
Molecular Formula:
C24H40N8O4
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 5 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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