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Product Details

Disopyramide | Antiarrhythmic

Disopyramide (3737-09-5) is a clinically useful sodium channel blocker used as an antiarrhythmic for treatment of ventricular tachycardia1 and hypertrophic cardiomyopathy2.  It decreases the rate of diastolic depolarization, decreases the upstroke velocity and increases the action potential duration of normal cardiac cells. It decreases the disparity between infarcted and normal myocardium refractory periods.  Disopyramide has no effect on α or β-adrenergic receptors but does display significant anticholinergic effects.3

References/Citations

1) Hell et al. (1978), Disopyramide: a review of its pharmacological properties and therapeutic use in treating cardiac arrhythmias; Drugs 115 331
2) Verlinden et al. (2015), Disopyramide for Hypertrophic Cardiomyopathy: A Pragmatic Reappraisal of an Old Drug; Pharmacotherapy, 35 1164
3) Nakajima et al. (1989), Anti-Cholinergic Effects of Quinidine, Disopyramide, and Procainamide in Isolated Atrial Myocytes: Mediation by Different Molecular Mechanisms; Circ. Res., 64 297

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Catalog#  10-4302-0050

$35.00
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CAS:
3737-09-5
Catalog Number:
10-4302
Activity:
Antiarrhythmic
Chemical Name:
4-(Diisopropylamino)-2-phenyl-2-(2-pyridyl)butyramide
Molecular Weight:
339.48
Molecular Formula:
C21H29N3O
Solubility:
Soluble in DMSO (25 mg/ml) and Ethanol (>35 mg/mL)
Physical Properties:
White solid
Purity:
>98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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