Divin | Divisome assembly inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $75.00 | ||
| 25 mg | $250.00 |
Divin (1443321-11-6) is an iron, cobalt, and copper chelator that arrests the late stages of cytokinesis in bacteria by blocking the physical process of constriction in dividing cells without affecting FtsZ. Iron starvation leads to transcriptional down-regulation of genes encoding proteins involved in cell division and affects the spatiotemporal localization of the divisome. Long-term treatment of bacteria with Divin resulted in cellular damage and prevented reactivation of the divisome even in the presence of iron-replete conditions. Iron deprivation is a potential adjuvant therapy for treating bacterial antibiotic resistance.
References/Citations:
1) Eun et al. (2013) Divin: A small molecule inhibitor of bacterial divisome assembly; J. Am. Chem. Soc. 135 9768
2) Santos et al. (2018) Small Molecule Chelators Reveal That Iron Starvation Inhibits Late Stages of Bacterial Cytokinesis; ACS Chem. Biol. 13 235
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Divin (1443321-11-6) is an iron, cobalt, and copper chelator that arrests the late stages of cytokinesis in bacteria by blocking the physical process of constriction in dividing cells without affecting FtsZ. Iron starvation leads to transcriptional down-regulation of genes encoding proteins involved in cell division and affects the spatiotemporal localization of the divisome. Long-term treatment of bacteria with Divin resulted in cellular damage and prevented reactivation of the divisome even in the presence of iron-replete conditions. Iron deprivation is a potential adjuvant therapy for treating bacterial antibiotic resistance.
References/Citations:
1) Eun et al. (2013) Divin: A small molecule inhibitor of bacterial divisome assembly; J. Am. Chem. Soc. 135 9768
2) Santos et al. (2018) Small Molecule Chelators Reveal That Iron Starvation Inhibits Late Stages of Bacterial Cytokinesis; ACS Chem. Biol. 13 235
Related products
-
Cilastatin Na | Protease inhibitor
From $60.00CAS:81129-83-1Catalog Number:10-2233Activity:Protease inhibitorChemical Name:(2Z)-7-[[(2R)-2-Amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]-carbonyl]amino]-2-heptenoic acid, sodium saltAlternate Names:MK 0791Molecular Weight:380.43Molecular Formula:C16H25N2O5SSolubility:Soluble in DMSO (up to 3 mg/ml) or in water (up to 35 mg/ml)Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.Shipping Code:RT -
D(+)-Cycloserine | NMDA, glycine site partial agonist
From $60.00CAS:68-41-7Catalog Number:10-2279Activity:NMDA, glycine site partial agonistChemical Name:(R)-4-Amino-3-isoxazolidoneMolecular Weight:102.09Molecular Formula:C3H6N2O2Solubility:Soluble in Water (up to 100 mg/ml)Physical Properties:White or off-white solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.Shipping Code:RT -
Thiostrepton | Antibiotic and FOXM1 inhibitor
From $85.00CAS:1393-48-2Catalog Number:10-2108Activity:Antibiotic and FOXM1 inhibitorChemical Name:Fermentation product from Streptomyces azureusMolecular Weight:1664.91Molecular Formula:C72H85N19O185Solubility:Soluble in DMSO (up to 15 mg/ml), or in Chloroform (up to 5 mg/ml).Physical Properties:Off-white solidPurity:98% by TLC and HPLCStorage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
