Divin | Divisome assembly inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $75.00 | ||
| 25 mg | $250.00 |
Divin (1443321-11-6) is an iron, cobalt, and copper chelator that arrests the late stages of cytokinesis in bacteria by blocking the physical process of constriction in dividing cells without affecting FtsZ. Iron starvation leads to transcriptional down-regulation of genes encoding proteins involved in cell division and affects the spatiotemporal localization of the divisome. Long-term treatment of bacteria with Divin resulted in cellular damage and prevented reactivation of the divisome even in the presence of iron-replete conditions. Iron deprivation is a potential adjuvant therapy for treating bacterial antibiotic resistance.
References/Citations:
1) Eun et al. (2013) Divin: A small molecule inhibitor of bacterial divisome assembly; J. Am. Chem. Soc. 135 9768
2) Santos et al. (2018) Small Molecule Chelators Reveal That Iron Starvation Inhibits Late Stages of Bacterial Cytokinesis; ACS Chem. Biol. 13 235
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Divin (1443321-11-6) is an iron, cobalt, and copper chelator that arrests the late stages of cytokinesis in bacteria by blocking the physical process of constriction in dividing cells without affecting FtsZ. Iron starvation leads to transcriptional down-regulation of genes encoding proteins involved in cell division and affects the spatiotemporal localization of the divisome. Long-term treatment of bacteria with Divin resulted in cellular damage and prevented reactivation of the divisome even in the presence of iron-replete conditions. Iron deprivation is a potential adjuvant therapy for treating bacterial antibiotic resistance.
References/Citations:
1) Eun et al. (2013) Divin: A small molecule inhibitor of bacterial divisome assembly; J. Am. Chem. Soc. 135 9768
2) Santos et al. (2018) Small Molecule Chelators Reveal That Iron Starvation Inhibits Late Stages of Bacterial Cytokinesis; ACS Chem. Biol. 13 235
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