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Product Details

Divin | Divisome assembly inhibitor

Divin is an iron, cobalt, and copper chelator that arrests the late stages of cytokinesis in bacteria by blocking the physical process of constriction in dividing cells without affecting FtsZ. Iron starvation leads to transcriptional down-regulation of genes encoding proteins involved in cell division and affects the spatiotemporal localization of the divisome. Long-term treatment of bacteria with Divin resulted in cellular damage and prevented reactivation of the divisome even in the presence of iron-replete conditions. Iron deprivation is a potential adjuvant therapy for treating bacterial antibiotic resistance.

References/Citations

1) Eun et al. (2013) Divin: A small molecule inhibitor of bacterial divisome assembly; J. Am. Chem. Soc. 135 9768
2) Santos et al. (2018) Small Molecule Chelators Reveal That Iron Starvation Inhibits Late Stages of Bacterial Cytokinesis; ACS Chem. Biol. 13 235

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Catalog#  10-4105-0005

$75.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
1443321-11-6
Catalog Number:
10-4105
Activity:
Divisome assembly inhibitor
Chemical Name:
N’-[(E)-(2-Hydroxynaphthalen-1-yl)methylidene]-3-(2-methyl-1H-benzimidazol-1-yl)propanehydrazide
Molecular Weight:
372.42
Molecular Formula:
C22H20N4O2
Solubility:
Soluble in DMSO (up to at least 25 mg/ml)
Physical Properties:
Pale yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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