IMP-1700 | Bacterial DNA repair inhibitor

IMP-1700 (1458674-25-3) is a potent inhibitor of the bacterial DNA double-strand break repair complex AddAB. It is capable of synergistic sensitization of methicillin-resistant staphylococcus aureus (MRSA) to ciprofloxacin (EC50 = 0.6nM).  IMP-1700 is an important new tool for exploring new treatment options for drug resistant bacteria.

References/Citations
1) Lim et al. (2019), Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus; Bioorg. Med. Chem., 27 114962

Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
Size:

10 mg, 50 mg

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CAS:
1458674-25-3
Catalog Number:
10-3950
Activity:
Bacterial DNA repair inhibitor
Chemical Name:
1-Cyclopropyl-6-fluoro-4-oxo-7-(4-(4-(trifluoromethyl)phenyl)carbamothioyl)piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid
Molecular Weight:
534.53
Molecular Formula:
C25H22F4N4O5S
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

IMP-1700 | Bacterial DNA repair inhibitor

$60.00$195.00

CAS:
1458674-25-3
Catalog Number:
10-3950
Activity:
Bacterial DNA repair inhibitor
Chemical Name:
1-Cyclopropyl-6-fluoro-4-oxo-7-(4-(4-(trifluoromethyl)phenyl)carbamothioyl)piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid
Molecular Weight:
534.53
Molecular Formula:
C25H22F4N4O5S
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT
  • 10 mg
  • 50 mg
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