DJ-V 159 | GPRC6A agonist; Stimulates insulin secretion in beta cells
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $50.00 | ||
| 25 mg | $200.00 |
GPRC6A is the receptor for osteocalcin as well as structurally unrelated ligands including L-amino acids, cations and anabolic steroids.1 GPRC6A is a potential therapeutic target for treating type 2 diabetes.2 DJ-V 159 (2253744-53-3) is an agonist at GPRC6A which activates ERK and upregulates cAMP levels in HEK-193 cells expressing GPRC6A. It stimulates insulin secretion in mouse β-cells and lowers blood glucose in mouse models.3
References/Citations:
1) Pi and Quarles (2012), Multiligand specificity and wide tissue expression of GPRC6A reveals new endocrine networks; Endocrinology, 153 2062
2) Pi et al. (2016), GPRC6A: Jack of all metabolism (or master of none); Mol. Metab., 6 185
3) Pi et al. (2018), Computationally identified novel agonists for GPRC6A; PLoS One, 13 e0195980
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
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GPRC6A is the receptor for osteocalcin as well as structurally unrelated ligands including L-amino acids, cations and anabolic steroids.1 GPRC6A is a potential therapeutic target for treating type 2 diabetes.2 DJ-V 159 (2253744-53-3) is an agonist at GPRC6A which activates ERK and upregulates cAMP levels in HEK-193 cells expressing GPRC6A. It stimulates insulin secretion in mouse β-cells and lowers blood glucose in mouse models.3
References/Citations:
1) Pi and Quarles (2012), Multiligand specificity and wide tissue expression of GPRC6A reveals new endocrine networks; Endocrinology, 153 2062
2) Pi et al. (2016), GPRC6A: Jack of all metabolism (or master of none); Mol. Metab., 6 185
3) Pi et al. (2018), Computationally identified novel agonists for GPRC6A; PLoS One, 13 e0195980
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