DMAPT | NFkB inhibitor

CAS:
870677-05-7
Catalog Number:
10-2825
Activity:
NFκB inhibitor
Chemical Name:
Dimethylamino-parthenolide
Molecular Weight:
293.41
Molecular Formula:
C17H27NO3
Solubility:
Soluble in DMSO, Ethyl acetate, or Ethanol.
Physical Properties:
White solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO, ethanol, or ethyl acetate may be stored at -20° for up to 1 month.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
5 mg$50.00
25 mg$175.00

DMAPT (870677-05-7) is a water soluble analog of the natural plant product parthenolide (Cat.# 10-2096) which suppresses in vivo tumor growth of two tobacco-associated neoplasms, lung and bladder cancer. It inhibits NFκB and stimulates the formation of reactive oxygen species which induced the activation of JNK.1 In non-small cell lung cancers DMAPT inhibits NFκB and DNA double-strand break repair.2

References/Citations:

1) Shanmugam et al. (2011), A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NFκB and generating reactive oxygen species; Int. J. Cancer, 128 2481
2) Estrabrook et al. (2011), Inhibition of NF-κB and DNA double-strand break repair by DMAPT sensitizes non-small-cell lung cancers to X-rays; Free Radic. Biol. Med., 51 2249

CAS:
870677-05-7
Catalog Number:
10-2825
Activity:
NFκB inhibitor
Chemical Name:
Dimethylamino-parthenolide
Molecular Weight:
293.41
Molecular Formula:
C17H27NO3
Solubility:
Soluble in DMSO, Ethyl acetate, or Ethanol.
Physical Properties:
White solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO, ethanol, or ethyl acetate may be stored at -20° for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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