Daunorubicin HCl | DNA Damaging Agent / Anticancer Agent
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $60.00 | ||
| 50 mg | $190.00 |
Daunorubicin HCl (23541-50-6) is an antitumor antibiotic used in the treatment of acute myeloid leukemias.1 Induces DNA damage by intercalation.2 Induces apoptosis in a variety of cell lines.3 Inhibition of autophagy with chloroquine enhances daunorubicin-induced apoptosis in K562 cells.4 Cell permeable.
References/Citations:
1) Laurent and Jaffrezou (2001), Signaling pathways activated by daunorubicin; Blood 98 913
2) Yang et al. (2014), Doxorubicin, DNA torsion, and chromatin dynamics; Biochim.Biophys.Acta, 1845 84
3) Masquelier et al. (2004), Relationship between daunorubicin concentration and apoptosis induction in leukemic cells; Biochem.Pharmacol. 67 1047
4) Han et al. (2011), Autophagy inhibition enhances daunorubicin-induced apoptosis in K562 cells; PLoS One 6 e28491
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Daunorubicin HCl (23541-50-6) is an antitumor antibiotic used in the treatment of acute myeloid leukemias.1 Induces DNA damage by intercalation.2 Induces apoptosis in a variety of cell lines.3 Inhibition of autophagy with chloroquine enhances daunorubicin-induced apoptosis in K562 cells.4 Cell permeable.
References/Citations:
1) Laurent and Jaffrezou (2001), Signaling pathways activated by daunorubicin; Blood 98 913
2) Yang et al. (2014), Doxorubicin, DNA torsion, and chromatin dynamics; Biochim.Biophys.Acta, 1845 84
3) Masquelier et al. (2004), Relationship between daunorubicin concentration and apoptosis induction in leukemic cells; Biochem.Pharmacol. 67 1047
4) Han et al. (2011), Autophagy inhibition enhances daunorubicin-induced apoptosis in K562 cells; PLoS One 6 e28491
Related products
-
Zileuton | 5-LO inhibitor
From $32.00CAS:111406-87-2Catalog Number:10-1098Activity:5-LO inhibitorChemical Name:N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyureaMolecular Weight:236.29Molecular Formula:C11H12N2O2SSolubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:White solidPurity:>98%
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.Shipping Code:RT -
Mifepristone | Glucocorticoid antagonist
From $50.00CAS:84371-65-3Catalog Number:10-1053Activity:Glucocorticoid antagonistAlternate Names:RU486Chemical Name:11β-[4-(Dimethylamino)phenyl]-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-oneMolecular Weight:429.59Molecular Formula:C29H35NO2Solubility:Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml).Physical Properties:Yellow solidPurity:>98% by TLCStorage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
Thalidomide | E3 UB ligase inhibitor
From $50.00CAS:50-35-1Catalog Number:10-1115Activity:E3 UB ligase inhibitorChemical Name:N-(2,6-Dioxo-3-piperidinyl)phthalimide, racemicMolecular Weight:258.25Molecular Formula:C13H10N2O4Solubility:Soluble in DMSO (up to 5 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
Website Created by Advanta Advertising LLC.