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Mifepristone | Glucocorticoid antagonist

Mifepristone (84371-65-3) is a cell-permeable steroid that is a potent antagonist at the progesterone and glucocorticoid receptors.1 It is used clinically as an abortifacient. KD progesterone receptor = 2.6 nM2 and KD glucocorticoid receptor = 0.4 nM3.

References/Citations
1) Cadepond et al. (1997) RU486 (Mifepristone): Mechanisms of action and clinical uses; Annu. Rev. Med. 48 129
2) Terakawa et al. (1988) RU486, a progestin antagonist, binds to progesterone receptors in a human endometrial cancer cell line and reverses the growth inhibition by progestins; J. Steroid Biochem. 31 161
3) Jung-Testas and Baulieu (1983) Inhibition of glucocorticosteroid action in cultured L-929 mouse fibroblasts by RU486, a new anti-glucocorticosteroid of high affinity for the glucocorticoidsteroid receptor; Exp. Cell Res. 147 177

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Focus Biomolecules cell signaling reagent supplier, Mifepristone | RU486 | Glucocorticoid antagonist | CAS 84371-65-3

Catalog#  10-1053

$50.00
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CAS:
84371-65-3
Catalog Number:
10-1053
Activity:
Glucocorticoid antagonist
Alternate Names:
RU486
Chemical Name:
11β-[4-(Dimethylamino)phenyl]-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one
Molecular Weight:
429.59
Molecular Formula:
C29H35NO2
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
Yellow solid
Purity:
>98% by TLC
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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