Domoic acid | Marine natural product neurotoxin
Domoic acid (DA; 14277-97-5)), a kainic acid-type neurotoxin produced by certain species of the marine pennate diatom Pseudo-nitzschia, is responsible for amnesic shellfish poisoning.1 Suspension feeders such as bivalve mollusks can accumulate and retain high amounts of DA in their tissues, threatening human health.2,3 DA is a potent agonist at kainate and AMPA receptors4 and induces convulsive behavior and seizures in rodents5. It induces structural and molecular changes in the developing zebra fish nervous system.6
References/Citations:
- Nie et al. (2022), Biosynthesis and detection of domoic acid from diatom Pseudo-nitzschia: A review; Curr. Pharm. Biotechnol., June 24 online ahead of print
- Garcia-Corona et al. (2022), First subcellular localization of the amnesic shellfish toxin, domoic acid, in bivalve tissues: Deciphering the physiological mechanisms involved in its long-retention in the king scallop Pecten Maximus; Harmful Algae, 116 102251
- Guillotin and Delcourt (2021), Marine Neurotoxins’ Effects on Environmental and Human Health: an OMICS Overview; Drugs, 20 18
- Hampson et al. (1992), Interaction of domoic acid and several derivatives with kainic acid and AMPA binding sites in rat brain; Eur. J. Pharmacol., 218 1
- Chiamulera et al. (1992), Domoic acid toxicity in rats and mice after intracerebroventricular administration: comparison with excitatory amino acid agonists; Pharmacol. Toxicol., 70 115
- Panlilio et al. (2020), Developmental Neurotoxicity of the Harmful Algal Bloom Toxin Domoic Acid: Cellular and Molecular Mechanisms Underlying Altered Behavior in the Zebrafish Model; Environ. Health Perspect., 128 117002
C15H21NO6
>97% HPLC
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Domoic acid (DA; 14277-97-5)), a kainic acid-type neurotoxin produced by certain species of the marine pennate diatom Pseudo-nitzschia, is responsible for amnesic shellfish poisoning.1 Suspension feeders such as bivalve mollusks can accumulate and retain high amounts of DA in their tissues, threatening human health.2,3 DA is a potent agonist at kainate and AMPA receptors4 and induces convulsive behavior and seizures in rodents5. It induces structural and molecular changes in the developing zebra fish nervous system.6
References/Citations:
- Nie et al. (2022), Biosynthesis and detection of domoic acid from diatom Pseudo-nitzschia: A review; Curr. Pharm. Biotechnol., June 24 online ahead of print
- Garcia-Corona et al. (2022), First subcellular localization of the amnesic shellfish toxin, domoic acid, in bivalve tissues: Deciphering the physiological mechanisms involved in its long-retention in the king scallop Pecten Maximus; Harmful Algae, 116 102251
- Guillotin and Delcourt (2021), Marine Neurotoxins’ Effects on Environmental and Human Health: an OMICS Overview; Drugs, 20 18
- Hampson et al. (1992), Interaction of domoic acid and several derivatives with kainic acid and AMPA binding sites in rat brain; Eur. J. Pharmacol., 218 1
- Chiamulera et al. (1992), Domoic acid toxicity in rats and mice after intracerebroventricular administration: comparison with excitatory amino acid agonists; Pharmacol. Toxicol., 70 115
- Panlilio et al. (2020), Developmental Neurotoxicity of the Harmful Algal Bloom Toxin Domoic Acid: Cellular and Molecular Mechanisms Underlying Altered Behavior in the Zebrafish Model; Environ. Health Perspect., 128 117002
Related products
-
DO264 | ABHD12 inhibitor
From $70.00CAS:2301866-59-9Catalog Number:10-3712Activity:ABHD12 inhibitorChemical Name:1-(1-(3-Chloro-4-(2-chloro-4-(trifluoromethyl)phenoxy)pyridin-2-yl)piperidin-4-yl)-3-(pyridin-3-yl)thioureaMolecular Weight:542.40Molecular Formula:C23H20Cl2F3N5OSSolubility:Soluble in DMSO (up to 30 mg/ml).Physical Properties:Pale yellow solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.Shipping Code:RT -
Ibrutinib | BTK inhibitor
From $40.00CAS:936563-96-1Catalog Number:10-4757Alternate Name:PCI-32765Activity:BTK inhibitor/Cancer immunotherapy enhancerChemical Name:1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-oneMolecular Weight:440.51Molecular Formula:C25H24N6O2Solubility:Soluble in DMSO ( up to at least 25 mg/ml)Physical Properties:White or off-white solidPurity:99% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
Rucaparib phosphate | PARP1 inhibitor
From $70.00CAS:459868-92-9Catalog Number:10-3321Activity:PARP1 inhibitorChemical Name:8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-oneAlternate Name:AG-14699; PF01367338Molecular Weight:421.36Molecular Formula:C19H18FN3O • H3PO4Solubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:Yellow solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
