Doramapimod | p38 MAPK inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $50.00 | ||
| 25 mg | $200.00 |
Doramapimod (285983-48-4) potently and selectively inhibits p38 MAPK by simultaneously binding to the ATP-binding domain and an allosteric site.1 (IC50=18 nM). Displays anti-inflammatory activity2 but differential effects on inflammatory genes3. Cell permeable.
References/Citations:
1) Pargellis et al. (2002), Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site; Nat. Struct. Biol., 9 268
2) Branger et al. (2002), Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia; J. Immunol., 168 4070
3) Joos et al. (2010), Differential effects of p38MAP kinase inhibitors on the expression of inflammation-associated genes in primary, interleukin-1 beta-stimulated human chondrocytes; Br. J. Pharmacol., 160 1252
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
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Doramapimod (285983-48-4) potently and selectively inhibits p38 MAPK by simultaneously binding to the ATP-binding domain and an allosteric site.1 (IC50=18 nM). Displays anti-inflammatory activity2 but differential effects on inflammatory genes3. Cell permeable.
References/Citations:
1) Pargellis et al. (2002), Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site; Nat. Struct. Biol., 9 268
2) Branger et al. (2002), Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia; J. Immunol., 168 4070
3) Joos et al. (2010), Differential effects of p38MAP kinase inhibitors on the expression of inflammation-associated genes in primary, interleukin-1 beta-stimulated human chondrocytes; Br. J. Pharmacol., 160 1252
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