Doramapimod | p38 MAPK inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $50.00 | ||
| 25 mg | $200.00 |
Doramapimod (285983-48-4) potently and selectively inhibits p38 MAPK by simultaneously binding to the ATP-binding domain and an allosteric site.1 (IC50=18 nM). Displays anti-inflammatory activity2 but differential effects on inflammatory genes3. Cell permeable.
References/Citations:
1) Pargellis et al. (2002), Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site; Nat. Struct. Biol., 9 268
2) Branger et al. (2002), Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia; J. Immunol., 168 4070
3) Joos et al. (2010), Differential effects of p38MAP kinase inhibitors on the expression of inflammation-associated genes in primary, interleukin-1 beta-stimulated human chondrocytes; Br. J. Pharmacol., 160 1252
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Doramapimod (285983-48-4) potently and selectively inhibits p38 MAPK by simultaneously binding to the ATP-binding domain and an allosteric site.1 (IC50=18 nM). Displays anti-inflammatory activity2 but differential effects on inflammatory genes3. Cell permeable.
References/Citations:
1) Pargellis et al. (2002), Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site; Nat. Struct. Biol., 9 268
2) Branger et al. (2002), Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia; J. Immunol., 168 4070
3) Joos et al. (2010), Differential effects of p38MAP kinase inhibitors on the expression of inflammation-associated genes in primary, interleukin-1 beta-stimulated human chondrocytes; Br. J. Pharmacol., 160 1252
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