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Product Details

Doramapimod | p38 MAPK inhibitor

Doramapimod (285983-48-4) potently and selectively inhibits p38 MAPK by simultaneously binding to the ATP-binding domain and an allosteric site.1 (IC50=18 nM). Displays anti-inflammatory activity2 but differential effects on inflammatory genes3. Cell permeable.

References/Citations

1) Pargellis et al. (2002), Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site; Nat. Struct. Biol., 9 268
2) Branger et al. (2002), Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia; J. Immunol., 168 4070
3) Joos et al. (2010), Differential effects of p38MAP kinase inhibitors on the expression of inflammation-associated genes in primary, interleukin-1 beta-stimulated human chondrocytesl; Br. J. Pharmacol., 160 1252

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Focus Biomolecules cell signaling reagent supplier, chemical structure of Doramapimod | p38 MAPK inhibitor | CAS 285983-48-4

Catalog#  10-2128-0005

$50.00
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CAS:
285983-48-4
Catalog Number:
10-2128
Activity:
p38 MAPK inhibitor
Chemical Name:
1-[5-tert-Butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalene-1-yl]urea
Alternate Names:
BIRB-796
Molecular Weight:
527.66
Molecular Formula:
C31H37N5O3
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml).
Physical Properties:
White or off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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