DRP1 inhibitor 4a | Mitochondrial fission inhibitor

CAS:
 N/A
Catalog Number:
 10-3912
DRP1 4a chemical structure Focus Biomolecules

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5 mg$80.00
25 mg$260.00

DRP1 inhibitor 4a blocks (IC50 = 100 nM) the protein-protein interaction between dynamin related protein 1 (DRP1) and the mitochondrial membrane receptor MiD49 preventing mitochondrial fragmentation.1  It prevented roughly half of mitochondrial fragmentation in A549 cells caused by carbonylcyanide-3-chlorophenylhydrazone (CCCP).

References/Citations:

  1. Furuya et al. (2023), Discovery of Potent Allosteric DRP1 Inhibitors by Disrupting Protein-Protein Interaction with MiD49; ACS Med. Chem. Lett. 14 1095
CAS:
N/A
Catalog Number:
10-3912
Activity:
Mitochondrial fission inhibitor
Chemical Names:
N-(4-Azetidin-1-yl)-2-phenylquinolin-6-yl)oxetane-3-carboxamide
Molecular Weight:
359.43
Molecular Formula:

C22H21N3O2

Solubility:
Soluble in DMSO (30 mg/ml)
Physical Properties:
Yellow solid
Purity:

>98% by HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored under an inert atmosphere at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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