DRP1 inhibitor 4a | Mitochondrial fission inhibitor
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $80.00 | ||
| 25 mg | $260.00 |
DRP1 inhibitor 4a blocks (IC50 = 100 nM) the protein-protein interaction between dynamin related protein 1 (DRP1) and the mitochondrial membrane receptor MiD49 preventing mitochondrial fragmentation.1 It prevented roughly half of mitochondrial fragmentation in A549 cells caused by carbonylcyanide-3-chlorophenylhydrazone (CCCP).
References/Citations:
- Furuya et al. (2023), Discovery of Potent Allosteric DRP1 Inhibitors by Disrupting Protein-Protein Interaction with MiD49; ACS Med. Chem. Lett. 14 1095
C22H21N3O2
>98% by HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
DRP1 inhibitor 4a blocks (IC50 = 100 nM) the protein-protein interaction between dynamin related protein 1 (DRP1) and the mitochondrial membrane receptor MiD49 preventing mitochondrial fragmentation.1 It prevented roughly half of mitochondrial fragmentation in A549 cells caused by carbonylcyanide-3-chlorophenylhydrazone (CCCP).
References/Citations:
- Furuya et al. (2023), Discovery of Potent Allosteric DRP1 Inhibitors by Disrupting Protein-Protein Interaction with MiD49; ACS Med. Chem. Lett. 14 1095
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