E-64 | Cysteine protease inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $47.00 | ||
| 25 mg | $190.00 |
E-64 (66701-25-5) is a cell-permeable, epoxysuccinyl peptide irreversible inhibitor of calpain and other cysteine proteases.1,2 Inhibits calpain-dependent apoptosis pathway in T cells3 but promotes heat-induced apoptosis in FM3A cells. Typical working concentration is 0.5-10 µg/ml.4
References/Citations
1) Wang and Yuen (1994), Calpain inhibition: an overview of its therapeutic potential; Trends Pharmacol. Sci., 15 412
2) Barrett et al. (1982), L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H, and L; Biochem. J., 201 189
3) Sarin et al. (1994), Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors; J. Immunol., 153 862
4) Zhu et al. (1996), Promotion of heat-induced apoptosis in FM3A cells by protease inhibitors; Biochem. Biophys. Res. Commun., 225 924
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
E-64 (66701-25-5) is a cell-permeable, epoxysuccinyl peptide irreversible inhibitor of calpain and other cysteine proteases.1,2 Inhibits calpain-dependent apoptosis pathway in T cells3 but promotes heat-induced apoptosis in FM3A cells. Typical working concentration is 0.5-10 µg/ml.4
References/Citations
1) Wang and Yuen (1994), Calpain inhibition: an overview of its therapeutic potential; Trends Pharmacol. Sci., 15 412
2) Barrett et al. (1982), L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H, and L; Biochem. J., 201 189
3) Sarin et al. (1994), Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors; J. Immunol., 153 862
4) Zhu et al. (1996), Promotion of heat-induced apoptosis in FM3A cells by protease inhibitors; Biochem. Biophys. Res. Commun., 225 924
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