Echinomycin | HIF-1alpha inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 1 mg | $90.00 | ||
| 5 mg | $380.00 |
Echinomycin (CAS 512-64-1) is a potent and selective hypoxia inducible factor 1α (HIF-1α) inhibitor. It binds to DNA via bifunctional intercalation, blocking the interaction of HIF-1α.1 Protects mice against relapsed acute myeloid leukemia with no effect on hematopoietic stem cells.2 Selectively eliminates cancer stem cells in mouse lymphoma and human AML xenogeneic models.3 A very useful tool for probing genes regulated by HIF1α.4
References/Citations
1) Kong et al. (2005), Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity; Cancer Res., 65 9047
2) Wang et al. (2014), Echinomycin protects mice against relapsed acute myeloid leukemia without adverse effect on hematopoietic stem cells; Blood, 124 1127
3) Wang et al. (2011), Targeting HIF1α eliminates cancer stem cells in hematological malignancies; Cell Stem Cell., 8 399
4) Li et al. (2015), Hypoxia-inducible factor-1α regulates the expression of L-type voltage-dependent Ca(2+) channels in PC12 cells under hypoxia; Cell Stress Chaperones, 20 507
NMR (Conforms)
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Product Data Sheet:
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Echinomycin (CAS 512-64-1) is a potent and selective hypoxia inducible factor 1α (HIF-1α) inhibitor. It binds to DNA via bifunctional intercalation, blocking the interaction of HIF-1α.1 Protects mice against relapsed acute myeloid leukemia with no effect on hematopoietic stem cells.2 Selectively eliminates cancer stem cells in mouse lymphoma and human AML xenogeneic models.3 A very useful tool for probing genes regulated by HIF1α.4
References/Citations
1) Kong et al. (2005), Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity; Cancer Res., 65 9047
2) Wang et al. (2014), Echinomycin protects mice against relapsed acute myeloid leukemia without adverse effect on hematopoietic stem cells; Blood, 124 1127
3) Wang et al. (2011), Targeting HIF1α eliminates cancer stem cells in hematological malignancies; Cell Stem Cell., 8 399
4) Li et al. (2015), Hypoxia-inducible factor-1α regulates the expression of L-type voltage-dependent Ca(2+) channels in PC12 cells under hypoxia; Cell Stress Chaperones, 20 507
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