Size: | Price | Quantity | |
---|---|---|---|
5 mg | $60.00 | ||
25 mg | $230.00 |
EGA (415687-81-9) is a novel selective inhibitor of endosomal trafficking which blocks cellular entry of lethal toxin and other acid-dependent bacterial toxins and viruses into mammalian cells.1 Inhibits Anthrax lethal toxin-induced RAW264.7 cell death, IC50=1.7 mM.1 Delays lysosomal targeting and degradation of the EGF receptor indicating that it targets host membrane trafficking.1 Does not block endosomal recycling of transferrin, retrograde trafficking of ricin, phagolysosomal trafficking or phagosome permeabilization by Franciscella tularensis, nor does it neutralize acidic organelles.1 Protects mammalian cells from Clostridium difficile CDT, Clostridium perfringens Iota toxin and Clostridium botulinum C2 toxin.2 A useful tool for exploring subcellular trafficking of various bacterial toxins.3
References/Citations:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
EGA (415687-81-9) is a novel selective inhibitor of endosomal trafficking which blocks cellular entry of lethal toxin and other acid-dependent bacterial toxins and viruses into mammalian cells.1 Inhibits Anthrax lethal toxin-induced RAW264.7 cell death, IC50=1.7 mM.1 Delays lysosomal targeting and degradation of the EGF receptor indicating that it targets host membrane trafficking.1 Does not block endosomal recycling of transferrin, retrograde trafficking of ricin, phagolysosomal trafficking or phagosome permeabilization by Franciscella tularensis, nor does it neutralize acidic organelles.1 Protects mammalian cells from Clostridium difficile CDT, Clostridium perfringens Iota toxin and Clostridium botulinum C2 toxin.2 A useful tool for exploring subcellular trafficking of various bacterial toxins.3
References/Citations:
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
For Postdoc
Customers!
Website Created by Advanta Advertising LLC.