Eltrombopag | Small molecule thrombopoietin agonist
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $55.00 | ||
| 25 mg | $165.00 |
Eltrombopag (496775-61-2) is a novel, orally active, small molecule human thrombopoietin receptor (TPO-R) agonist, EC50=0.27 μM.1,2 Maintains human hematopoietic stem and progenitor cells under inflammatory conditions.3 Promotes DNA repair in human hematopoietic stem and progenitor cells.4 Acts as a powerful chelator of cellular and extracellular iron(III).5 Stimulates hematopoietic stem cells via a TPO-R-independent mechanism involving iron chelation.6
References/Citations:
1) Xie et al. (2018), Pharmacological characterization of eltrombopag, a novel orally active human thrombopoietin receptor agonist; J. Cell. Mol. Med., 22 5367
2) Erickson-Miller et al. (2008), Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist; Stem Cells, 27 424
3) Alvarado et al. (2019), Eltrombopag maintains human hematopoietic stem and progenitor cells under inflammatory conditions mediated by IFN-γ; Blood, 133 2043
4) Guenther et al. (2019), Eltrombopag promotes DNA repair in human hematopoietic stem and progenitor cells; Exp. Hematol. 73 1
5) Vlachodimitropoulou et al. (2017), Eltrombopag: a powerful chelator of cellular or extracellular iron (II) alone or combined with a second chelator; Blood, 130 1923
6) Kao et al. (2018), Thrombopoietin receptor-independent stimulation of hematopoietic stem cells by eltrombopag; Science Transl. Med., 10 eaas9563
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Eltrombopag (496775-61-2) is a novel, orally active, small molecule human thrombopoietin receptor (TPO-R) agonist, EC50=0.27 μM.1,2 Maintains human hematopoietic stem and progenitor cells under inflammatory conditions.3 Promotes DNA repair in human hematopoietic stem and progenitor cells.4 Acts as a powerful chelator of cellular and extracellular iron(III).5 Stimulates hematopoietic stem cells via a TPO-R-independent mechanism involving iron chelation.6
References/Citations:
1) Xie et al. (2018), Pharmacological characterization of eltrombopag, a novel orally active human thrombopoietin receptor agonist; J. Cell. Mol. Med., 22 5367
2) Erickson-Miller et al. (2008), Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist; Stem Cells, 27 424
3) Alvarado et al. (2019), Eltrombopag maintains human hematopoietic stem and progenitor cells under inflammatory conditions mediated by IFN-γ; Blood, 133 2043
4) Guenther et al. (2019), Eltrombopag promotes DNA repair in human hematopoietic stem and progenitor cells; Exp. Hematol. 73 1
5) Vlachodimitropoulou et al. (2017), Eltrombopag: a powerful chelator of cellular or extracellular iron (II) alone or combined with a second chelator; Blood, 130 1923
6) Kao et al. (2018), Thrombopoietin receptor-independent stimulation of hematopoietic stem cells by eltrombopag; Science Transl. Med., 10 eaas9563
Related products
-
DMPO | Spin trap
From $45.00CAS:3317-61-1Catalog Number:10-2299Activity:Spin trapChemical Name:5,5-Dimethyl-1-pyrroline N-oxideMolecular Weight:113.16Molecular Formula:C6H11NOSolubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:Pale yellow oil or low melting point solidPurity:99% by HPLCStorage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Protect from exposure to light and moisture. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT -
U-74389G | Free radical scavenger
From $60.00CAS:153190-29-5Catalog Number:10-1110Activity:Free radical scavengerChemical Name:21-[4-(2,6-Di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]pregna-1,4,9[11]-triene-3,20-dione maleate saltMolecular Weight:726.9Molecular Formula:C37H50N6O2 C4H4O4Solubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
Mitoquinone | Mitochondria-targeted antioxidant
From $70.00CAS:444890-41-9Catalog Number:10-1363Activity:Mitochondria-targeted antioxidantChemical Name:10-(6′-Ubiquinonyl)decyltriphenylphosphonium bromideMolecular Weight:663.64Molecular Formula:C37H44BrO4PSolubility:Soluble in DMSO (70 mg/mL); ethanol (30 mg/mL)Physical Properties:Brown waxy solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
