EN450 | NFkB1 molecular glue
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $80.00 | ||
| 25 mg | $275.00 |
EN450 (793719-01-4) is a molecular glue that covalently interacts with a cysteine residue on the E2 ubiquitin ligase UBE2D. It displayed anti-proliferative effects in HAP1 leukemia cells. EN450s antiproliferative effects were elicited via proteasome-dependent degradation of nuclear factor kappa B subunit 1(NFkB1).1
References/Citations:
- King et al. (2023), Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-kB; Cell Chem. Biol. 30 394
C11H13ClN2O3S
>98% HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
EN450 (793719-01-4) is a molecular glue that covalently interacts with a cysteine residue on the E2 ubiquitin ligase UBE2D. It displayed anti-proliferative effects in HAP1 leukemia cells. EN450s antiproliferative effects were elicited via proteasome-dependent degradation of nuclear factor kappa B subunit 1(NFkB1).1
References/Citations:
- King et al. (2023), Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-kB; Cell Chem. Biol. 30 394
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