Eniluracil | Dihydropyrimidine dehydrogenase inhibitor

CAS:
59989-18-3
Catalog Number:
10-4600
Activity:
Dihydropyrimidine dehydrogenase inhibitor
Chemical Name:
5-Ethynyluracil
Alternate Names:
GW776C85
Molecular Weight:
136.11
Molecular Formula:
C6H4N2O2
Solubility:
Soluble in DMSO
Physical Properties:
Yellow solid
Purity:
97% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
10 mg$40.00
50 mg$125.00
This product is also available in the following library:

Eniluracil (59989-18-3) is an irreversible dihydropyrimidine dehydrogenase (DPD) inhibitor.1-3  DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU).  Eniluracil has been used along with 5-FU to prolong circulating concentrations of the drug.

References/Citations:

1) Porter et al. (1992), Mechanism-based Inactivation of Dihydropyrimidine Dehydrogenase by 5-Ethynyluracil; J. Biol. Chem., 267 5236
2) Baccalnari et al. (1993), 5-Ethynyluracil (776C85): a potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil; Proc. Natl. Acad. Sci. USA, 90 11064
3) Schilsky and Kindler (2000) Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase; Expert Opin. Investig. Drugs, 9 1635

CAS:
59989-18-3
Catalog Number:
10-4600
Activity:
Dihydropyrimidine dehydrogenase inhibitor
Chemical Name:
5-Ethynyluracil
Alternate Names:
GW776C85
Molecular Weight:
136.11
Molecular Formula:
C6H4N2O2
Solubility:
Soluble in DMSO
Physical Properties:
Yellow solid
Purity:
97% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

20% OFF

For Postdoc
Customers!