Epalrestat | Aldose reductase inhibitor
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $50.00 | ||
| 25 mg | $160.00 |
Epalrestat (82159-09-9) is an aldose reductase inhibitor (IC50 = 10 nM (rat lens) and 25 nM (human placenta).1,2 It reduces sorbitol accumulation in the sciatic nerve, erythrocytes and ocular tissue. Epalrestat may be used to prevent or slow the progression of diabetic neuropathy.3
References/Citations:
1) Kikkawa et al. (1983) Effect of a new aldose reductase inhibitor, (E)-3-carboxymethyl-5-[(2E)-methyl-3-phenylpropenylidene]rhodanine (ONO-2235), on peripheral nerve disorders in streptozotocin diabetic rats; Diabetologica, 24 290
2) Terashima et al. (1984) Effects of a new aldose reductase inhibitor on various tissues in vitro; J. Pharmacol. Exp. Ther., 229 226
3) Ramirez and Borja (2008) Epalrestat: an aldose reductase inhibitor for the treatment of diabetic neuropathy; Pharmacotherapy, 28 646
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Epalrestat (82159-09-9) is an aldose reductase inhibitor (IC50 = 10 nM (rat lens) and 25 nM (human placenta).1,2 It reduces sorbitol accumulation in the sciatic nerve, erythrocytes and ocular tissue. Epalrestat may be used to prevent or slow the progression of diabetic neuropathy.3
References/Citations:
1) Kikkawa et al. (1983) Effect of a new aldose reductase inhibitor, (E)-3-carboxymethyl-5-[(2E)-methyl-3-phenylpropenylidene]rhodanine (ONO-2235), on peripheral nerve disorders in streptozotocin diabetic rats; Diabetologica, 24 290
2) Terashima et al. (1984) Effects of a new aldose reductase inhibitor on various tissues in vitro; J. Pharmacol. Exp. Ther., 229 226
3) Ramirez and Borja (2008) Epalrestat: an aldose reductase inhibitor for the treatment of diabetic neuropathy; Pharmacotherapy, 28 646
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1-855-FOCUS21
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