BML-278 | SIRT1 activator

CAS:
120533-76-8
Catalog Number:
10-1063
Activity:
SIRT1 activator
Chemical Name:
N-Benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine
Molecular Weight:
391.47
Molecular Formula:
C24H25NO4
Solubility:
Soluble in DMSO (up to 5 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
5 mg$60.00
25 mg$240.00

BML-278 (120533-76-8) is a structurally novel activator of SIRT1 (EC50=1 μM). Displays selectivity over SIRT2 and 3 (EC50=25 and 50 μM respectively). Cell permeable.

References/Citations:

1) Mai et al. (2009), Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors; J. Med.Chem.,52 5496

CAS:
120533-76-8
Catalog Number:
10-1063
Activity:
SIRT1 activator
Chemical Name:
N-Benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine
Molecular Weight:
391.47
Molecular Formula:
C24H25NO4
Solubility:
Soluble in DMSO (up to 5 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee