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Apicidin | HDAC inhibitor

Apicidin (183506-66-3) is a fungal toxin that is a potent, cell permeable inhibitor of histone deacetylases (HDAC's).1 It also displays antitumor properties by inducing changes in p21WAF1/Cip1 and gelsolin gene expression causing cell cycle arrest in the G1 phase.2 Apicidin dramatically decreases HIF-1α protein levels and transcriptional activity in human and mouse tumor cell lines.3

References/Citations
1) Darkin-Rattray, et al. (1996) Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase; Proc. Nat. Acad. Sci. USA, 93 13143
2) Han et al. (2000) Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin; Cancer Res., 60 6068
3) Kim et al. (2007) Regulation of the HIF-1alpha stability by histone deacetylases; Oncol. Rep. 17 647

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Focus Biomolecules cell signaling reagent supplier, chemical structure of Apicidin | HDAC inhibitor | CAS 183506-66-3

Catalog#  10-2057

$55.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
183506-66-3
Catalog Number:
10-2057
Activity:
HDAC inhibitor
Chemical Name:
Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinexcarbonyl]
Molecular Weight:
623.78
Molecular Formula:
C34H49N5O6
Solubility:
Soluble in DMSO (up to 1 mg/ml)
Physical Properties:
White solid
Purity:
>98%
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. Compound is prone to oxidation. Protect from exposure to air.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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