Apicidin (183506-66-3) is a fungal toxin that is a potent, cell permeable inhibitor of histone deacetylases (HDAC's).¹ It also displays antitumor properties by inducing changes in p21WAF1/Cip1 and gelsolin gene expression causing cell cycle arrest in the G₁ phase.² Apicidin dramatically decreases HIF-1α protein levels and transcriptional activity in human and mouse tumor cell lines.³

References/Citations
1) Darkin-Rattray, et al. (1996) Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase; Proc. Nat. Acad. Sci. USA, 93 13143
2) Han et al. (2000) Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin; Cancer Res., 60 6068
3) Kim et al. (2007) Regulation of the HIF-1alpha stability by histone deacetylases; Oncol. Rep. 17 647