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Epirubicin HCl | DNA damaging agent

Epirubicin HCl (56390-09-1) is an antitumor agent1. Inhibits topoisomerase II2. Induces DNA damage by a number of different mechanisms including intercalation, free radical-mediated oxidation, crosslinking, interference with DNA unwinding, strand separation and helicase activity3. Epirubicin HCl induces myocardial disfunction as a side effect to chemotherapy4.

1) Cersosimo et al. (1986), Epirubicin: a review of the pharmacology, clinical activity, and adverse effects of an adriamycin analogue; J. Clin. Oncol., 4 425
2) Spadari et al. (1986), DNA polymerases and DNA topoisomerases as targets for the development of anticancer drugs; Anticancer Res., 6 935
3) Minotti et al. (2004), Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity; Pharmacol. Rev., 56 185
4) Mercuro et al. (2007), Early epirubicin-induced myocardial dysfunction revealed by serial tissue Doppler echocardiography: correlation with inflammatory and oxidative stress markers; Oncologist, 12 1124

Focus Biomolecules cell signaling supplier, chemical structure of Epirubicin HCl | DNA damaging agent | CAS 56390-09-1

Catalog#  10-2761

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Catalog Number:
DNA damaging agent
Chemical Name:
Molecular Weight:
Molecular Formula:
C27H29NO11 HCl
Soluble in DMSO (up to 50 mg/ml), or in Water (up to 5 mg/ml).
Physical Properties:
Red orange solid
97% by TLC
NMR (Conforms)
Storage Temperature:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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