EV-96 | Cysteine-reactive T cell activation suppressor

CAS:
 N/A
Catalog Number:
 10-3949
EV-96 chemical structure Focus Biomolecules

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5 mg$90.00
25 mg$295.00

EV-96 is a cysteine-reactive immunosuppressive agent that suppresses T cell activation (EC50 <2.5 µM) via inhibition of NF-kB activation and degradation of key immune-relevant proteins including ITK, TEC, and CYTIP.1

References/Citations:

  1. Vinogradova et al. (2020), An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells; Cell 182 P1009
CAS:
N/A
Catalog Number:
10-3949
Activity:
Cysteine-reactive T cell activation suppressor
Chemical Names:
Methyl (1R,3S)-2-acryloyl)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
Molecular Weight:
404.42
Molecular Formula:

C23H20N2O5

Solubility:
Soluble in DMSO (at least 40 mg/ml)
Physical Properties:
White to off-white solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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