Fascaplysin | CDK4 inhibitor
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 1 mg | $40.00 | ||
| 5 mg | $160.00 |
Fascaplysin (114719-57-2) is a novel marine natural product isolated from Thorectandra sp.1 A potent and selective inhibitor of cyclin dependent kinase 4/cyclin D1 (IC50 = 0.35 μM) and is less selective for Cdk6/D1 (IC50 = 3.4 μM). Displays antiangiogenic acitivity.2 Fascaplysin displays high cytotoxic activity against small cell lung cancer cell lines acting via multiple mechanisms including topoisomerase I, DNA integrity and ROS.3
References/Citations:
1) Soni et al. (2000), Inhibition of cyclin-dependent kinase 4 (Cdk4) by fascaplysin, a marine natural product; Biochem. Biophys. Res. Commun., 275 877
2) Lin et al. (2007), Fascaplysin, a selective CDK4 inhibitor, exhibit anti-angiogenic activity in vitro and in vivo; Cancer Chemother. Pharmacol., 59 439
3) Hamilton et al. (2014), Cytotoxic effects of fascaplysin against small cell lung cancer cell lines; Mar. Drugs, 12 1377
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Fascaplysin (114719-57-2) is a novel marine natural product isolated from Thorectandra sp.1 A potent and selective inhibitor of cyclin dependent kinase 4/cyclin D1 (IC50 = 0.35 μM) and is less selective for Cdk6/D1 (IC50 = 3.4 μM). Displays antiangiogenic acitivity.2 Fascaplysin displays high cytotoxic activity against small cell lung cancer cell lines acting via multiple mechanisms including topoisomerase I, DNA integrity and ROS.3
References/Citations:
1) Soni et al. (2000), Inhibition of cyclin-dependent kinase 4 (Cdk4) by fascaplysin, a marine natural product; Biochem. Biophys. Res. Commun., 275 877
2) Lin et al. (2007), Fascaplysin, a selective CDK4 inhibitor, exhibit anti-angiogenic activity in vitro and in vivo; Cancer Chemother. Pharmacol., 59 439
3) Hamilton et al. (2014), Cytotoxic effects of fascaplysin against small cell lung cancer cell lines; Mar. Drugs, 12 1377
Related products
-
Bortezomib | Proteasome inhibitor
From $60.00CAS:179324-69-7Catalog Number:10-2120Activity:Proteasome inhibitorAlternate Names:MG-341, PS-341Chemical Name:N-(2-Pyrazine)carbonyl-L-phenylalanine-L-leucine boronic acidMolecular Weight:384.25Molecular Formula:C19H25BN4O4Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 35 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (conforms)Storage Temperature:-20°Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT -
NNGH | MMP inhibitor (pan specific)
From $55.00CAS:161314-17-6Catalog Number:10-1045Activity:MMP inhibitor (pan spec.)Chemical Name:N-Isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acidMolecular Weight:316.38Molecular Formula:C13H20N2O5SSolubility:Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 8 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
Sorafenib | Multi-kinase inhibitor
From $40.00CAS:284461-73-0Catalog Number:10-2174Activity:Inhibitor of Raf-1 and other kinasesAlternate Names:BAY 43-9006Chemical Name:4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamideMolecular Weight:464.83Molecular Formula:C21H16ClF3N4O3Solubility:Soluble in DMSO (up to 200 mg/ml) or in Ethanol (up to 3 mg/ml).Physical Properties:Off-white solidPurity:99% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
