Fascaplysin | CDK4 inhibitor
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 1 mg | $40.00 | ||
| 5 mg | $160.00 |
Fascaplysin (114719-57-2) is a novel marine natural product isolated from Thorectandra sp.1 A potent and selective inhibitor of cyclin dependent kinase 4/cyclin D1 (IC50 = 0.35 μM) and is less selective for Cdk6/D1 (IC50 = 3.4 μM). Displays antiangiogenic acitivity.2 Fascaplysin displays high cytotoxic activity against small cell lung cancer cell lines acting via multiple mechanisms including topoisomerase I, DNA integrity and ROS.3
References/Citations:
1) Soni et al. (2000), Inhibition of cyclin-dependent kinase 4 (Cdk4) by fascaplysin, a marine natural product; Biochem. Biophys. Res. Commun., 275 877
2) Lin et al. (2007), Fascaplysin, a selective CDK4 inhibitor, exhibit anti-angiogenic activity in vitro and in vivo; Cancer Chemother. Pharmacol., 59 439
3) Hamilton et al. (2014), Cytotoxic effects of fascaplysin against small cell lung cancer cell lines; Mar. Drugs, 12 1377
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Fascaplysin (114719-57-2) is a novel marine natural product isolated from Thorectandra sp.1 A potent and selective inhibitor of cyclin dependent kinase 4/cyclin D1 (IC50 = 0.35 μM) and is less selective for Cdk6/D1 (IC50 = 3.4 μM). Displays antiangiogenic acitivity.2 Fascaplysin displays high cytotoxic activity against small cell lung cancer cell lines acting via multiple mechanisms including topoisomerase I, DNA integrity and ROS.3
References/Citations:
1) Soni et al. (2000), Inhibition of cyclin-dependent kinase 4 (Cdk4) by fascaplysin, a marine natural product; Biochem. Biophys. Res. Commun., 275 877
2) Lin et al. (2007), Fascaplysin, a selective CDK4 inhibitor, exhibit anti-angiogenic activity in vitro and in vivo; Cancer Chemother. Pharmacol., 59 439
3) Hamilton et al. (2014), Cytotoxic effects of fascaplysin against small cell lung cancer cell lines; Mar. Drugs, 12 1377
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