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Fascaplysin | CDK4 inhibitor

Fascaplysin (114719-57-2) is a novel marine natural product isolated from Thorectandra sp.1 A potent and selective inhibitor of cyclin dependent kinase 4/cyclin D1 (IC50 = 0.35 μM) and is less selective for Cdk6/D1 (IC50 = 3.4 μM). Displays antiangiogenic acitivity.2 Fascaplysin displays high cytotoxic activity against small cell lung cancer cell lines acting via multiple mechanisms including topoisomerase I, DNA integrity and ROS.3

References/Citations
1) Soni et al. (2000), Inhibition of cyclin-dependent kinase 4 (Cdk4) by fascaplysin, a marine natural product; Biochem. Biophys. Res. Commun., 275 877
2) Lin et al. (2007), Fascaplysin, a selective CDK4 inhibitor, exhibit anti-angiogenic activity in vitro and in vivo; Cancer Chemother. Pharmacol., 59 439
3) Hamilton et al. (2014), Cytotoxic effects of fascaplysin against small cell lung cancer cell lines; Mar. Drugs, 12 1377

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Focus Biomolecules cell signaling reagent supplier, chemical structure of Fascaplysin | CDK4 inhibitor | CAS 114718-57-2

Catalog#  10-1517

$40.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
114719-57-2
Catalog Number:
10-1517
Activity:
CDK4 inhibitor
Chemical Name:
12,13-Dihydro-13-oxopyrido[1,2-a:3,4-b']diindol-5-ium chloride
Molecular Weight:
306.75
Molecular Formula:
C18H11ClN2O4
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Water (up to 2 mg/ml)
Physical Properties:
Dark red-brown solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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