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Fascaplysin | CDK4 inhibitor

Fascaplysin (114719-57-2) is a novel marine natural product isolated from Thorectandra sp.1 A potent and selective inhibitor of cyclin dependent kinase 4/cyclin D1 (IC50 = 0.35 μM) and is less selective for Cdk6/D1 (IC50 = 3.4 μM). Displays antiangiogenic acitivity.2 Fascaplysin displays high cytotoxic activity against small cell lung cancer cell lines acting via multiple mechanisms including topoisomerase I, DNA integrity and ROS.3

1) Soni et al. (2000), Inhibition of cyclin-dependent kinase 4 (Cdk4) by fascaplysin, a marine natural product; Biochem. Biophys. Res. Commun., 275 877
2) Lin et al. (2007), Fascaplysin, a selective CDK4 inhibitor, exhibit anti-angiogenic activity in vitro and in vivo; Cancer Chemother. Pharmacol., 59 439
3) Hamilton et al. (2014), Cytotoxic effects of fascaplysin against small cell lung cancer cell lines; Mar. Drugs, 12 1377

Focus Biomolecules cell signaling reagent supplier, chemical structure of Fascaplysin | CDK4 inhibitor | CAS 114718-57-2

Catalog#  10-1517

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Catalog Number:
CDK4 inhibitor
Chemical Name:
12,13-Dihydro-13-oxopyrido[1,2-a:3,4-b']diindol-5-ium chloride
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 20 mg/ml) or in Water (up to 2 mg/ml)
Physical Properties:
Dark red-brown solid
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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