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Alsterpaullone | GSK3b inhibitor and CDK5/p25 inhibitor

Alsterpaullone (237430-03-4) is a potent and selective inhibitor of GSK-3β and CDK5/p25. Potent inhibitor of CDK1/cyclin B (IC50 = 35 nM)1. Alsterpaullone induces apoptosis2 and inhibits angiogenesis3.

References/Citations
1) Bain et al. (2003), The specificities of protein kinase inhibitors: an update; Biochem. J., 371 199
2) Lahusen et al. (2003), Alsterpaullone, a novel cyclin-dependent kinase inhibitor, induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential; Mol. Carcinog., 36 183
3) Zahler et al. (2010), Anti-angiogenic potential of small molecular inhibitors of cyclin dependent kinases in vitro; Angiogenesis, 13 239

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Alsterpaullone | 237430-03-4 | Structure | Supplier

Catalog#  10-1397

$56.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
237430-03-4
Catalog Number:
10-1397
Activity:
GSK3β inhibitor, CDK5/p25 inhibitor
Chemical Name:
9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5)-one
Molecular Weight:
293.28
Molecular Formula:
C16H11N3O3
Solubility:
Soluble in DMSO (up to 10 mg/ml).
Physical Properties:
Brown solid
Purity:
96% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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