Fasnall HCl | Fatty acid synthase inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $66.00 | ||
| 25 mg | $264.00 |
Fasnall (CAS 929978-58-5) is a potent and selective fatty acid synthase (FASN) inhibitor acting via interfering with cofactor binding.1 IC50s = 147 and 213 nM respectively for inhibition of acetate and glucose incorporation into total lipids in HepG2 cells. IC50=5.84 μM in an isolated enzyme assay. Displays potent antitumor activity in the MMTV-Neu HER2+ breast cancer model.1 Reduces HIV-1 virion production by 90% (EC50=213 nM).2
References/Citations:
1) Alwarawrah et al. (2016) Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer, Cell Chem. Biol., 23 678
2) Kulkarni et al. (2017), Cellular fatty acid synthase is required for late stages of HIV-1 replication; Retrovirology, 14 45
NMR (Conforms)
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Product Data Sheet:
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Fasnall (CAS 929978-58-5) is a potent and selective fatty acid synthase (FASN) inhibitor acting via interfering with cofactor binding.1 IC50s = 147 and 213 nM respectively for inhibition of acetate and glucose incorporation into total lipids in HepG2 cells. IC50=5.84 μM in an isolated enzyme assay. Displays potent antitumor activity in the MMTV-Neu HER2+ breast cancer model.1 Reduces HIV-1 virion production by 90% (EC50=213 nM).2
References/Citations:
1) Alwarawrah et al. (2016) Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer, Cell Chem. Biol., 23 678
2) Kulkarni et al. (2017), Cellular fatty acid synthase is required for late stages of HIV-1 replication; Retrovirology, 14 45
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