Fasudil HCl | ROCK inhibitor

CAS:
105628-07-7
Catalog Number:
10-2137
Activity:
ROCK inhibitor
Alternate Names:
HA-1077
Chemical Name:
1-(5-Isoquinolinesulfonyl)homopiperazine HCl
Molecular Weight:
327.84
Molecular Formula:
C14H17N3O2S HCl
Solubility:
Soluble in DMSO (up to 75 mg/ml) or in Water (up to 100 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
50 mg$52.00
250 mg$155.00

Fasudil HCl (105628-07-7) is a Rho-associated kinase inhibitor (IC50 = 1.9 μM and 10.7 μM for Rho-associated kinase II and Rho-associated kinase respectively)1. Inhibits other kinases including cyclic nucleotide-dependent protein kinases.1 Fasudil HCl reduces tryptamine-evoked vasopressor responses.2 Attenuates bleomycin-induced pulmonary fibrosis in a mouse model.3 Clinically useful vasodilator.

References/Citations:

1) Davies et al. (2000), Specificity and mechanism of action of some commonly used protein kinase inhibitors; Biochem. J., 351 95
2) Anwar et al. (2013), Signal transduction and modulating pathways in tryptamine-evoked vasopressor responses of the rat isolated perfused mesenteric bed; Vascul. Pharmacol., 58 140
3) Jiang et al. (2012), Fasudil, a rho-kinase inhibitor, attenuates bleomycin-induced pulmonary fibrosis in mice; Int. J. Mol. Sci., 13 8293

CAS:
105628-07-7
Catalog Number:
10-2137
Activity:
ROCK inhibitor
Alternate Names:
HA-1077
Chemical Name:
1-(5-Isoquinolinesulfonyl)homopiperazine HCl
Molecular Weight:
327.84
Molecular Formula:
C14H17N3O2S HCl
Solubility:
Soluble in DMSO (up to 75 mg/ml) or in Water (up to 100 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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