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Product Details

Fasudil HCl | ROCK inhibitor

Fasudil HCl (105628-07-7) is a Rho-associated kinase inhibitor (IC50 = 1.9 μM and 10.7 μM for Rho-associated kinase II and Rho-associated kinase respectively)1. Inhibits other kinases including cyclic nucleotide-dependent protein kinases.1 Fasudil HCl reduces tryptamine-evoked vasopressor responses.2 Attenuates bleomycin-induced pulmonary fibrosis in a mouse model.3 Clinically useful vasodilator.

References/Citations
1) Davies et al. (2000), Specificity and mechanism of action of some commonly used protein kinase inhibitors; Biochem. J., 351 95
2) Anwar et al. (2013), Signal transduction and modulating pathways in tryptamine-evoked vasopressor responses of the rat isolated perfused mesenteric bed; Vascul. Pharmacol., 58 140
3) Jiang et al. (2012), Fasudil, a rho-kinase inhibitor, attenuates bleomycin-induced pulmonary fibrosis in mice; Int. J. Mol. Sci., 13 8293

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Focus Biomolecules cell signaling reagent supplier, chemical structure of Fasudil HCl | ROCK inhibitor | CAS 105628-07-7

Catalog#  10-2137-0050

$45.00
Quantity
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CAS:
105628-07-7
Catalog Number:
10-2137
Activity:
ROCK inhibitor
Alternate Names:
HA-1077
Chemical Name:
1-(5-Isoquinolinesulfonyl)homopiperazine HCl
Molecular Weight:
327.84
Molecular Formula:
C14H17N3O2S HCl
Solubility:
Soluble in DMSO (up to 75 mg/ml) or in Water (up to 100 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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