Fasudil HCl (105628-07-7) is a Rho-associated kinase inhibitor (IC50 = 1.9 μM and 10.7 μM for Rho-associated kinase II and Rho-associated kinase respectively)1. Inhibits other kinases including cyclic nucleotide-dependent protein kinases.1 Fasudil HCl reduces tryptamine-evoked vasopressor responses.2 Attenuates bleomycin-induced pulmonary fibrosis in a mouse model.3 Clinically useful vasodilator.
1) Davies et al. (2000), Specificity and mechanism of action of some commonly used protein kinase inhibitors; Biochem. J., 351 95
2) Anwar et al. (2013), Signal transduction and modulating pathways in tryptamine-evoked vasopressor responses of the rat isolated perfused mesenteric bed; Vascul. Pharmacol., 58 140
3) Jiang et al. (2012), Fasudil, a rho-kinase inhibitor, attenuates bleomycin-induced pulmonary fibrosis in mice; Int. J. Mol. Sci., 13 8293