Fatostatin | SREBP activation inhibitor

CAS:
125256-00-0
Catalog Number:
10-1355
Activity:
SREBP activation inhibitor
Chemical Name:
2-(2-Propylpyridin-4-yl)-4-(p-tolyl)thiazole
Molecular Weight:
294.42
Molecular Formula:
C18H18N2S
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Available Options

size :PriceQuantity 
5 mg$50.00
25 mg$200.00
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Fatostatin (125256-00-0) blocks adipogenesis by inhibiting the activation of SREBP. Inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein (SCAP). Fatostatin prevents increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice.1 Inhibits high glucose-induced TGF-β in mesangial cells.2 Cell permeable.

References/Citations:

1) Kamisuki et al. (2009), A small molecule that blocks fat synthesis by inhibiting the activation of SREBP; Chem. Biol., 16 882
2) Uttarwar et al. (2012), SREBP-1 activation by glucose mediates TGF-β upregulation in mesangial cells; Am. J. Physiol. Renal Physiol., 302 F329

CAS:
125256-00-0
Catalog Number:
10-1355
Activity:
SREBP activation inhibitor
Chemical Name:
2-(2-Propylpyridin-4-yl)-4-(p-tolyl)thiazole
Molecular Weight:
294.42
Molecular Formula:
C18H18N2S
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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