FB23-2 | FTO inhibitor
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $60.00 | ||
| 25 mg | $240.00 |
FB23-2 (2243736-45-8) is an inhibitor (IC50 = 2.6 µM) of the mRNA m6A demethylase fat-mass- and obesity-associated protein (FTO).1 Displays significant anti-proliferative activity in NB4 (IC50 = 0.8 µM) and MONOMAC6 (IC50 = 1.5 µM) cells. Selective against the RNA demethylase ALKB5. FB23-2 induced myeloid differentiation and apoptosis in acute myeloid leukemia cells. FB23-2 suppressed the proliferation and migration of hepatocellular carcinoma cells via suppressing the expression of the kinase ERBB3 and human tubulin beta class Iva (TUBB4A).2
References/Citations:
- Huang et al. (2019), Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia; Cancer Cell. 35 677
- Jiang et al. (2024), Targeting FTO suppresses hepatocellular carcinoma by inhibiting ERBB3 and TUBB4A expression; Biochem. Pharmacol. 226 116375
C18H15Cl2N3O3
98% HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
FB23-2 (2243736-45-8) is an inhibitor (IC50 = 2.6 µM) of the mRNA m6A demethylase fat-mass- and obesity-associated protein (FTO).1 Displays significant anti-proliferative activity in NB4 (IC50 = 0.8 µM) and MONOMAC6 (IC50 = 1.5 µM) cells. Selective against the RNA demethylase ALKB5. FB23-2 induced myeloid differentiation and apoptosis in acute myeloid leukemia cells. FB23-2 suppressed the proliferation and migration of hepatocellular carcinoma cells via suppressing the expression of the kinase ERBB3 and human tubulin beta class Iva (TUBB4A).2
References/Citations:
- Huang et al. (2019), Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia; Cancer Cell. 35 677
- Jiang et al. (2024), Targeting FTO suppresses hepatocellular carcinoma by inhibiting ERBB3 and TUBB4A expression; Biochem. Pharmacol. 226 116375
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