Felodipine | L-type Ca channel blocker

CAS:
72509-76-3
Catalog Number:
10-2020
Activity:
L-type Ca channel blocker
Chemical Name:
3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Molecular Weight:
384.25
Molecular Formula:
C18H19Cl2NO4
Solubility:
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 35 mg/ml).
Physical Properties:
White solid
Purity:
>98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Available Options

size :PriceQuantity 
10 mg$50.00
50 mg$120.00

Felodipine (72509-76-3) is a potent L-type Ca2+ channel blocker that is selective over N-, R-, P/Q- and T-type channels.1,2 It displays high vascular selectivity over cardiac muscle, thus lowering arterial blood pressure without altering cardiac contractility. Felodipine is used in the clinic as an antihypertensive agent.

References/Citations:

1) Todd and Faulds, (1992) Felodipine. A review of the pharmacology and therapeutic use of the extended release formulation in cardiovascular disorders; Drugs 44 251
2) Furukawa et al. (1999) Selectivities of Dihydropyridine Derivatives in Blocking Ca2+ Channel Subtypes Expressed in Xenopus Oocytes; J. Pharmacol. Exp. Ther. 291 464

CAS:
72509-76-3
Catalog Number:
10-2020
Activity:
L-type Ca channel blocker
Chemical Name:
3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Molecular Weight:
384.25
Molecular Formula:
C18H19Cl2NO4
Solubility:
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 35 mg/ml).
Physical Properties:
White solid
Purity:
>98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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