Filgotinib | JAK1 inhibitor

CAS:
1206161-97-8
Catalog Number:
10-5145
Activity:
JAK1 inhibitor
Chemical Names:
N-[5-[4-[(1,1-dioxido-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5-ɑ]pyridin-2-yl]-cyclopropanecarboxamide
GLPG0634; GS-6034
Molecular Weight:
425.50
Molecular Formula:
C21H23N5O3S
Solubility:
Soluble in DMSO (15 mg/ml with warming)
Physical Properties:
Off-white solid
Purity:
98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
5 mg$65.00
25 mg$220.00

Filgotinib (1206161-97-8) is a potent and selective JAK1 inhibitor (IC50s=10, 28, 810 and 116 nM for JAK1, JAK2, JAK3 and TYK2 respectively).2  Displays potent anti-inflammatory activity in various models.1,2  Effective as a monotherapy in patients with active rheumatoid arthritis.3 Reverses oncostatin M-mediated inhibition of rat stem Leydig cell differentiation.4

References:

  1. Menet et al. (2014), Triazolopyridines as selective JAK1 inhibitors: from hit identification to GLPG0634; Med. Chem., 57 9323
  2. Rompaey et al. (2013), Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases; Immunol., 191 3568
  3. Kavanaugh et al. (2017), Filgotinib (GLPG0634/GS-6034), an oral selective JAK1 inhibitor, is effective as monotherapy in patients with active rheumatoid arthritis: results from a randomized dose-finding study (DARWIN 2); Rheum. Dis., 76 1009
  4. Wang et al.  (2019), Oncostatin M inhibits differentiation of rat stem Leydig cells in vivo and in vitro; J. Cell. Mol. Med., 23 426
CAS:
1206161-97-8
Catalog Number:
10-5145
Activity:
JAK1 inhibitor
Chemical Names:
N-[5-[4-[(1,1-dioxido-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5-ɑ]pyridin-2-yl]-cyclopropanecarboxamide
GLPG0634; GS-6034
Molecular Weight:
425.50
Molecular Formula:
C21H23N5O3S
Solubility:
Soluble in DMSO (15 mg/ml with warming)
Physical Properties:
Off-white solid
Purity:
98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

20% OFF

For Postdoc
Customers!