Filipin III | Cholesterol probe
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 1 mg | $130.00 | ||
| 5 mg | $500.00 |
Filipin III (480-49-9) is a polyene macrolide antibiotic. It may be used in a double staining procedure for the detection of lipoproteins.1 Binds specifically to cholesterol forming a fluorescent complex which may be used for staining.2 Disrupts the lipid raft/caveolae endocytosis pathway.3 Prevents pathological prion protein accumulation by reducing endocytosis and inducing cellular PrP release.4
References/Citations:
1) Smejkal and Hof (1994), Cholesterol-specific probe for lipoproteins immobilized on nitrocellulose membranes; Biotechniques, 16 68
2) Bornig and Geyer (1974), Staining of cholesterol with the fluorescent antibiotic “filipin”; Acta Histochemica, 50 110
3) Huo et al. (2003), Lipid rafts/caveolae are essential for insulin-like growth factor-1 receptor signaling during 3T3-L1 preadipocyte differentiation induction; J. Biol. Chem., 278 11561
4) Marella et al. (2002), Filipin prevents pathological prion protein accumulation by reducing endocytosis and inducing cellular PrP release; J. Biol. Chem., 277 25457
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Filipin III (480-49-9) is a polyene macrolide antibiotic. It may be used in a double staining procedure for the detection of lipoproteins.1 Binds specifically to cholesterol forming a fluorescent complex which may be used for staining.2 Disrupts the lipid raft/caveolae endocytosis pathway.3 Prevents pathological prion protein accumulation by reducing endocytosis and inducing cellular PrP release.4
References/Citations:
1) Smejkal and Hof (1994), Cholesterol-specific probe for lipoproteins immobilized on nitrocellulose membranes; Biotechniques, 16 68
2) Bornig and Geyer (1974), Staining of cholesterol with the fluorescent antibiotic “filipin”; Acta Histochemica, 50 110
3) Huo et al. (2003), Lipid rafts/caveolae are essential for insulin-like growth factor-1 receptor signaling during 3T3-L1 preadipocyte differentiation induction; J. Biol. Chem., 278 11561
4) Marella et al. (2002), Filipin prevents pathological prion protein accumulation by reducing endocytosis and inducing cellular PrP release; J. Biol. Chem., 277 25457
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