FK-866 HCl | NAD biosynthesis inhibitor

CAS:
658084-64-1 (base)
Catalog Number:
10-1109
Activity:
NAD biosynthesis inhibitor
Molecular Weight:
427.98
Molecular Formula:
C24H29N3O2 HCl
Solubility:
Soluble in Water (up to 40 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Material is hygroscopic, must be desiccated. Solutions in distilled water may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
5 mg$70.00
25 mg$280.00
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FK866 HCl (658084-64-1 base) is a nicotinamide phosphoribosyltransferase inhibitor (Ki=0.4 nM). Induces tumor cell apoptosis. FK-866 HCl extends lifespan of human cells. Cell permeable.

References/Citations:

1) Hasmann et al. (2003), FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis;  Cancer Res., 63 7436
2) Van der Veer et al. (2007), Extension of human cell lifespan by nicotinamide phosphoribosyltransferase;  J. Biol. Chem., 282 10841

CAS:
658084-64-1 (base)
Catalog Number:
10-1109
Activity:
NAD biosynthesis inhibitor
Molecular Weight:
427.98
Molecular Formula:
C24H29N3O2 HCl
Solubility:
Soluble in Water (up to 40 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Material is hygroscopic, must be desiccated. Solutions in distilled water may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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