Flavopiridol HCl | CDK inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $50.00 | ||
| 25 mg | $200.00 |
Flavopiridol HCl (131740-09-5) is a cyclin-dependent kinase (CDK) inhibitor that causes cell cycle arrest at G1 and G2 phase.1 Potentiates (100-200 nM) PMA-induced apoptosis in HL-60 and U937 cells.2 Potentiates the effects of topoisomerase I inhibitors by suppressing Rad51 expression in a p53-dependent manner. Flavopiridol HCl displays potent antiviral activity against HIV-1 and HSV-1 in vitro.4
References/Citations:
1) Kaur et al. (1992), Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275; J. Natl. Cancer Inst., 84 1736
2) Cartee et al. (2002), Synergistic induction of apoptosis in human myeloid leukemia cells by phorbol 12-myristate 13-acetate and flavopiridol proceeds via activation of both the intrinsic and tumor necrosis factor-mediated extrinsic cell death pathways; Mol. Pharmacol., 61 1313
3) Ambrosini et al. (2008), The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner; Cancer Res. 68 2312
4) Schang et al. (2004), Effects of pharmacological cyclin-dependent kinase inhibitors on viral transcription and replication; Biochim. Biophys. Acta, 1697 197
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Flavopiridol HCl (131740-09-5) is a cyclin-dependent kinase (CDK) inhibitor that causes cell cycle arrest at G1 and G2 phase.1 Potentiates (100-200 nM) PMA-induced apoptosis in HL-60 and U937 cells.2 Potentiates the effects of topoisomerase I inhibitors by suppressing Rad51 expression in a p53-dependent manner. Flavopiridol HCl displays potent antiviral activity against HIV-1 and HSV-1 in vitro.4
References/Citations:
1) Kaur et al. (1992), Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275; J. Natl. Cancer Inst., 84 1736
2) Cartee et al. (2002), Synergistic induction of apoptosis in human myeloid leukemia cells by phorbol 12-myristate 13-acetate and flavopiridol proceeds via activation of both the intrinsic and tumor necrosis factor-mediated extrinsic cell death pathways; Mol. Pharmacol., 61 1313
3) Ambrosini et al. (2008), The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner; Cancer Res. 68 2312
4) Schang et al. (2004), Effects of pharmacological cyclin-dependent kinase inhibitors on viral transcription and replication; Biochim. Biophys. Acta, 1697 197
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