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Product Details

FLI-06 | Notch pathway inhibitor

FLI-06 (313967-18-9) was discovered in a screen designed to monitor the trafficking and processing of a ligand-independent Notch-enhanced GFP reporter. It was found to disrupt the Golgi apparatus in a manner distinct from that of brefeldin A. It inhibited general secretion at a step before exit from the ER which was accompanied by a tubule-to-sheet morphological transition of the ER. Thus FLI-06 is the first small molecule acting at such an early stage in secretory traffic1.

References/Citations
1) Kramer et al., (2013), Small molecules intercept Notch signaling and the early secretory pathway; Nat. Chem. Biol. 9 731

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FLI-06 | 313967-18-9 | Structure | Supplier

Catalog#  10-1504

$80.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
313967-18-9
Catalog Number:
10-1504
Activity:
Notch pathway inhibitor
Molecular Weight:
438.52
Molecular Formula:
C25H30N2O5
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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