Flumazenil | Benzodiazepine antagonist
8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, ethyl ester
Ro 1722; Ro 15-1788
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 20 mg | $50.00 | ||
| 100 mg | $200.00 |
Flumazenil (78755-81-4) is a benzodiazepine antagonist1, panspecific for α1, α2, α3 or α5-containing GABAA receptors2. Reduces withdrawal sequelae in benzodiazepine dependence.3 Reverses the toxic effects, including coma and respiratory depression of zolpidem intoxication4 and gabapentin-induced coma5.
References/Citations:
- Möhler et al. (1981), Benzodiazepine antagonist Ro 15-1788; binding characteristics and interaction with drug-induced changes in dopamine turnover and cerebellar cGMP levels; J. Neurochem., 37 714
- Doble et al. (1999), New insights into the mechanism of action of hypnotics; Psychopharmacol., 13(4 Suppl. 1) S11
- Hood et al. (2014), Benzodiazepine dependence and its treatment with low dose flumazenil; J. Clin. Pharmacol., 77 285
- Lheureux et al. (1990), Zolpidem intoxication mimicking narcotic overdose: response to flumazenil; Exp. Toxicol., 9 105
- Masciullo et al. (2021), Flumazenil therapy for a gabapentin-induced coma: a case report; Med. Case Rep., 15 242
8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, ethyl ester
Ro 1722; Ro 15-1788
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Flumazenil (78755-81-4) is a benzodiazepine antagonist1, panspecific for α1, α2, α3 or α5-containing GABAA receptors2. Reduces withdrawal sequelae in benzodiazepine dependence.3 Reverses the toxic effects, including coma and respiratory depression of zolpidem intoxication4 and gabapentin-induced coma5.
References/Citations:
- Möhler et al. (1981), Benzodiazepine antagonist Ro 15-1788; binding characteristics and interaction with drug-induced changes in dopamine turnover and cerebellar cGMP levels; J. Neurochem., 37 714
- Doble et al. (1999), New insights into the mechanism of action of hypnotics; Psychopharmacol., 13(4 Suppl. 1) S11
- Hood et al. (2014), Benzodiazepine dependence and its treatment with low dose flumazenil; J. Clin. Pharmacol., 77 285
- Lheureux et al. (1990), Zolpidem intoxication mimicking narcotic overdose: response to flumazenil; Exp. Toxicol., 9 105
- Masciullo et al. (2021), Flumazenil therapy for a gabapentin-induced coma: a case report; Med. Case Rep., 15 242
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