Flupirtine maleate | K+ channel activator
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 50 mg | $55.00 | ||
| 100 mg | $100.00 |
Flupirtine maleate (75507-68-5) activates KV7 potassium channels1, indirectly antagonizes NMDA receptors, and modulates GABAA receptors2. Displays neuroprotective actions in a model of cerebral ischemia in mice and reduces apoptosis and necrosis induced by noxious stimuli. Analgesic activity.3 Active in vivo.
References/Citations:
1) Azad et al. (2004), The potassium channel modulator flupirtine shifts the frequency-response function of hippocampal synapses to favour LTD in mice; Neuro. Sci. Lett., 370 186
2) Klinger et al. (2012), Concomitant facilitation of GABAA receptors and KV7 channels by the non-opioid analgesic flupirtine; Br. J. Pharmacol., 166 1631
3) Osbourne et al. (1998), Flupirtine, a nonopioid centrally acting analgesic, acts as an NMDA antagonist; Gen. Pharmacol., 30 255
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
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Flupirtine maleate (75507-68-5) activates KV7 potassium channels1, indirectly antagonizes NMDA receptors, and modulates GABAA receptors2. Displays neuroprotective actions in a model of cerebral ischemia in mice and reduces apoptosis and necrosis induced by noxious stimuli. Analgesic activity.3 Active in vivo.
References/Citations:
1) Azad et al. (2004), The potassium channel modulator flupirtine shifts the frequency-response function of hippocampal synapses to favour LTD in mice; Neuro. Sci. Lett., 370 186
2) Klinger et al. (2012), Concomitant facilitation of GABAA receptors and KV7 channels by the non-opioid analgesic flupirtine; Br. J. Pharmacol., 166 1631
3) Osbourne et al. (1998), Flupirtine, a nonopioid centrally acting analgesic, acts as an NMDA antagonist; Gen. Pharmacol., 30 255
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