Flupirtine maleate | K+ channel activator

CAS:
75507-68-5
Catalog Number:
10-2416
Activity:
K+ channel activator
Chemical Name:
N-[2-Amino-6-[[(4-fluorophenyl)methyl]amino]-3-pyridinyl]carbamic acid ethyl ester maleate
Alternate Names:
D9998
Molecular Weight:
420.39
Molecular Formula:
C15H17FN4O2 • C4H4O4
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 4 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
50 mg$55.00
100 mg$100.00

Flupirtine maleate (75507-68-5) activates KV7 potassium channels1, indirectly antagonizes NMDA receptors, and modulates GABAA receptors2. Displays neuroprotective actions in a model of cerebral ischemia in mice and reduces apoptosis and necrosis induced by noxious stimuli. Analgesic activity.3 Active in vivo.

References/Citations:

1) Azad et al. (2004), The potassium channel modulator flupirtine shifts the frequency-response function of hippocampal synapses to favour LTD in mice; Neuro. Sci. Lett., 370 186
2) Klinger et al. (2012), Concomitant facilitation of GABAA receptors and KV7 channels by the non-opioid analgesic flupirtine; Br. J. Pharmacol., 166 1631
3) Osbourne et al. (1998), Flupirtine, a nonopioid centrally acting analgesic, acts as an NMDA antagonist; Gen. Pharmacol., 30 255

CAS:
75507-68-5
Catalog Number:
10-2416
Activity:
K+ channel activator
Chemical Name:
N-[2-Amino-6-[[(4-fluorophenyl)methyl]amino]-3-pyridinyl]carbamic acid ethyl ester maleate
Alternate Names:
D9998
Molecular Weight:
420.39
Molecular Formula:
C15H17FN4O2 • C4H4O4
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 4 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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