Fluvastatin Na | HMG CoA reductase inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 20 mg | $40.00 | ||
| 100 mg | $130.00 |
Fluvastatin Na (CAS 93957-55-2) is a potent inhibitor of HMG-CoA reductase, IC50=40-100 nM.1 Clinically useful, orally active antihypercholesterolemic agent. Inhibits vascular smooth muscle proliferation, IC50=70 nM.2 Displays antineuroinflammatory activity.3 Prevents lung adenocarcinoma bone metastasis by triggering autophagy.4 Attenuates cell proliferation in hepatocellular carcinoma.5
References/Citations:
1) Dansette et al. (2000), HMG-CoA reductase activity in human liver microsomes: comparative inhibition by statins; Exp. Toxicol. Pathol., 52 145
2) Turner et al. (2007), Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion: J. Cardiovasc. Pharmacol., 50 458
3) McFarland et al. (2017), Statins Reduce Lipopolysaccharide-Induced Cytokine and Inflammatory Mediator Release in an In Vitro Model of Microglial-like Cells; Mediators Inflamm., 2582745
4) Yang et al. (2017), Fluvastatin Prevents Lung Adenocarcinoma Bone Metastasis by Triggering Autophagy; EBioMedicine, 19 49
5)Higashi et al. (2016), Statin attenuates cell proliferative ability via TAZ (WWTR1) in hepatocellular carcinoma; Med. Oncol., 33 123
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
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Fluvastatin Na (CAS 93957-55-2) is a potent inhibitor of HMG-CoA reductase, IC50=40-100 nM.1 Clinically useful, orally active antihypercholesterolemic agent. Inhibits vascular smooth muscle proliferation, IC50=70 nM.2 Displays antineuroinflammatory activity.3 Prevents lung adenocarcinoma bone metastasis by triggering autophagy.4 Attenuates cell proliferation in hepatocellular carcinoma.5
References/Citations:
1) Dansette et al. (2000), HMG-CoA reductase activity in human liver microsomes: comparative inhibition by statins; Exp. Toxicol. Pathol., 52 145
2) Turner et al. (2007), Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion: J. Cardiovasc. Pharmacol., 50 458
3) McFarland et al. (2017), Statins Reduce Lipopolysaccharide-Induced Cytokine and Inflammatory Mediator Release in an In Vitro Model of Microglial-like Cells; Mediators Inflamm., 2582745
4) Yang et al. (2017), Fluvastatin Prevents Lung Adenocarcinoma Bone Metastasis by Triggering Autophagy; EBioMedicine, 19 49
5)Higashi et al. (2016), Statin attenuates cell proliferative ability via TAZ (WWTR1) in hepatocellular carcinoma; Med. Oncol., 33 123
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