Focus on cellular senescence and life extension

In a paper just out in Nature Aging, Goro Katsuumi and coworkers in Tokyo demonstrated that inhibition of sodium-glucose co-transporter 2 (SGLT2) with canagliflozin enhanced clearance of senescent cells. In a mouse model of dietary obesity canagliflozin reduced senescence load in visceral adipose tissue and improved adipose tissue inflammation and metabolic dysfunction. Furthermore, canagliflozin treatment extended the lifespan of mice with premature aging even when treatment was started in middle age.