Formononetin | PPARgamma activator; increases adipocyte thermogenesis
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 20 mg | $50.00 | ||
| 100 mg | $150.00 |
Formononetin (485-72-3) is a naturally occurring isoflavone isolated from Astragalus and other plants. Increases adipocyte thermogenesis by modulating PPARγ activity.1 Activates AMP-activated protein kinase/β-catenin signaling to inhibit adipogenesis.2 Accelerates wound repair by increasing expression of Egr-1 transcription factor.3 Potential cancer chemopreventive and chemotherapeutic.4 Provides neuroprotection against traumatic brain injury by inhibition of neuroinflammation in a rat model.5
References/Citations:
1) Nie et al. (2018), The natural compound, formononetin, extracted from Astragalus membranaceus increases adipocyte thermogenesis by modulating PPARγ activity; Br. J. Pharmacol., 175 1439
2) Gautam et al. (2017), Formononetin, an isoflavone, activates AMO-activated protein kinase/ßβ-catenin signaling to inhibit adipogenesis and rescues C57BL/6 mice from high-fat diet-induced obesity and bone loss; Br. J. Nutrit., 117 645
3) Huh et al. (2011), Formononetin accelerates wound repair by the regulation of early growth response factor-1 transcription factor through the phosphorylation of the ERK and p38 MAPK pathways; Int. Immunopharmacol., 11 46
4) Ong et al. (2019), Focus on Formononetin: Anticancer Potential and Molecular Targets; Cancers (Basel), 11 E611
5) Li et al. (2018), Neuroprotective effect of formononetin against TBI in rats via suppressing inflammatory reaction in cortical neurons; Biomed. Pharmacother., 106 349
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Formononetin (485-72-3) is a naturally occurring isoflavone isolated from Astragalus and other plants. Increases adipocyte thermogenesis by modulating PPARγ activity.1 Activates AMP-activated protein kinase/β-catenin signaling to inhibit adipogenesis.2 Accelerates wound repair by increasing expression of Egr-1 transcription factor.3 Potential cancer chemopreventive and chemotherapeutic.4 Provides neuroprotection against traumatic brain injury by inhibition of neuroinflammation in a rat model.5
References/Citations:
1) Nie et al. (2018), The natural compound, formononetin, extracted from Astragalus membranaceus increases adipocyte thermogenesis by modulating PPARγ activity; Br. J. Pharmacol., 175 1439
2) Gautam et al. (2017), Formononetin, an isoflavone, activates AMO-activated protein kinase/ßβ-catenin signaling to inhibit adipogenesis and rescues C57BL/6 mice from high-fat diet-induced obesity and bone loss; Br. J. Nutrit., 117 645
3) Huh et al. (2011), Formononetin accelerates wound repair by the regulation of early growth response factor-1 transcription factor through the phosphorylation of the ERK and p38 MAPK pathways; Int. Immunopharmacol., 11 46
4) Ong et al. (2019), Focus on Formononetin: Anticancer Potential and Molecular Targets; Cancers (Basel), 11 E611
5) Li et al. (2018), Neuroprotective effect of formononetin against TBI in rats via suppressing inflammatory reaction in cortical neurons; Biomed. Pharmacother., 106 349
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