FSG67 | GPAT inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 10 mg | $65.00 | ||
| 50 mg | $215.00 |
FSG67 (1158383-34-6) is an inhibitor of Glycerol 3-Phosphate Acyltransferase (GPAT); IC50 = 24 μM.1 It was able to reduce food intake, decrease body weight and adiposity, enhance energy utilization as fatty acid oxidation, reverse hepatic steatosis, and enhance insulin sensitivity in diet-induced obese mice while showing no in vitro or in vivo toxicity.2 FSG67 also caused decreased gene expression for orexigenic hypothalamic neuropeptides AgRP and NPY.2 FSG67 increased FAOx in primary hypothalamic neurons (PHN) leading to an increase in ATP and inactivation of AMPK. Oxidative stress and indicators of ER stress were also reduced in PHN.3
References/Citations:
1) Wydysh et al. (2009), Design and Synthesis of Small Molecule Glycerol 3-Phosphate Acyltransferase Inhibitors; J. Med. Chem., 52 3317
2) Kuhajda et al. (2011), Pharmacological glycerol-3-phosphate acyltransferase inhibition decreases food intake and adiposity and increases insulin sensitivity; Am. J. Physiol. Regul. Integr. Comp. Physiol., 301 R116
3) McFadden et al. (2014), Increasing Fatty Acid Oxidation Remodels the Hypothalamic Neurometabolome to Mitigate Stress and Inflammation; PLoS ONE, 9 e115642
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
FSG67 (1158383-34-6) is an inhibitor of Glycerol 3-Phosphate Acyltransferase (GPAT); IC50 = 24 μM.1 It was able to reduce food intake, decrease body weight and adiposity, enhance energy utilization as fatty acid oxidation, reverse hepatic steatosis, and enhance insulin sensitivity in diet-induced obese mice while showing no in vitro or in vivo toxicity.2 FSG67 also caused decreased gene expression for orexigenic hypothalamic neuropeptides AgRP and NPY.2 FSG67 increased FAOx in primary hypothalamic neurons (PHN) leading to an increase in ATP and inactivation of AMPK. Oxidative stress and indicators of ER stress were also reduced in PHN.3
References/Citations:
1) Wydysh et al. (2009), Design and Synthesis of Small Molecule Glycerol 3-Phosphate Acyltransferase Inhibitors; J. Med. Chem., 52 3317
2) Kuhajda et al. (2011), Pharmacological glycerol-3-phosphate acyltransferase inhibition decreases food intake and adiposity and increases insulin sensitivity; Am. J. Physiol. Regul. Integr. Comp. Physiol., 301 R116
3) McFadden et al. (2014), Increasing Fatty Acid Oxidation Remodels the Hypothalamic Neurometabolome to Mitigate Stress and Inflammation; PLoS ONE, 9 e115642
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1-855-FOCUS21
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